Maternal serum activin A is not elevated before preeclampsia in women who are at high risk

C.A. Blackburn, Jeffrey Keelan, R.S. Taylor, R.A. North

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    11 Citations (Scopus)

    Abstract

    OBJECTIVE: The purpose of this study was to determine whether, in women who are at high risk of the development of preeclampsia, serum activin A concentrations are elevated before the disease and whether activin A is a useful predictor of preeclampsia.STUDY DESIGN: Sera were collected on five occasions throughout pregnancy from women with chronic hypertension, renal disease, or previous early-onset preeclampsia (n = 80 women). Women were classified as control subjects normotensive or stable chronic hypertension), gestational hypertensive, or preeclamptic (de novo or superimposed). Serum activin A concentrations were measured by immunoassay. Differences in activin A concentrations between groups were analyzed with the use of a mixed-models procedure; screening test characteristics were calculated.RESULTS: Twenty-six women (33%) had gestational hypertension, and 17 women (21%) had preeclampsia or superimposed preeclampsia. Serum activin A levels increased with gestation in all groups (P =.00011), but there were no significant difference in activin A levels between groups (P = .75).CONCLUSION: In women who were at high risk of the development of preeclampsia, serum activin A levels are not elevated with preeclampsia. Activin A is not a useful predictor of preeclampsia in this setting.
    Original languageEnglish
    Pages (from-to)807-811
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume188
    Issue number3
    DOIs
    Publication statusPublished - 2003

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