Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Nicolas Vidart d'Egurbide Bagazgoitia, Helen D. Bailey, Laurent Orsi, Brigitte Lacour, Lea Guerrini-Rousseau, Anne-Isabelle Bertozzi, Pierre Leblond, Cecile Faure-Conter, Isabelle Pellier, Claire Freycon, Francois Doz, Stephanie Puget, Stephane Ducassou, Jacqueline Clavel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalInternational Journal of Cancer
Volume142
Issue number3
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Cite this

Vidart d'Egurbide Bagazgoitia, Nicolas ; Bailey, Helen D. ; Orsi, Laurent ; Lacour, Brigitte ; Guerrini-Rousseau, Lea ; Bertozzi, Anne-Isabelle ; Leblond, Pierre ; Faure-Conter, Cecile ; Pellier, Isabelle ; Freycon, Claire ; Doz, Francois ; Puget, Stephanie ; Ducassou, Stephane ; Clavel, Jacqueline. / Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors : A pooled analysis of the ESCALE and ESTELLE studies (SFCE). In: International Journal of Cancer. 2018 ; Vol. 142, No. 3. pp. 489-497.
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title = "Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)",
abstract = "Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95{\%} confidence intervals (95{\%} CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95{\%} CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT.",
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Vidart d'Egurbide Bagazgoitia, N, Bailey, HD, Orsi, L, Lacour, B, Guerrini-Rousseau, L, Bertozzi, A-I, Leblond, P, Faure-Conter, C, Pellier, I, Freycon, C, Doz, F, Puget, S, Ducassou, S & Clavel, J 2018, 'Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE)' International Journal of Cancer, vol. 142, no. 3, pp. 489-497. https://doi.org/10.1002/ijc.31073

Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors : A pooled analysis of the ESCALE and ESTELLE studies (SFCE). / Vidart d'Egurbide Bagazgoitia, Nicolas; Bailey, Helen D.; Orsi, Laurent; Lacour, Brigitte; Guerrini-Rousseau, Lea; Bertozzi, Anne-Isabelle; Leblond, Pierre; Faure-Conter, Cecile; Pellier, Isabelle; Freycon, Claire; Doz, Francois; Puget, Stephanie; Ducassou, Stephane; Clavel, Jacqueline.

In: International Journal of Cancer, Vol. 142, No. 3, 01.02.2018, p. 489-497.

Research output: Contribution to journalArticle

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T1 - Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors

T2 - A pooled analysis of the ESCALE and ESTELLE studies (SFCE)

AU - Vidart d'Egurbide Bagazgoitia, Nicolas

AU - Bailey, Helen D.

AU - Orsi, Laurent

AU - Lacour, Brigitte

AU - Guerrini-Rousseau, Lea

AU - Bertozzi, Anne-Isabelle

AU - Leblond, Pierre

AU - Faure-Conter, Cecile

AU - Pellier, Isabelle

AU - Freycon, Claire

AU - Doz, Francois

AU - Puget, Stephanie

AU - Ducassou, Stephane

AU - Clavel, Jacqueline

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N2 - Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT.

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KW - CANCER

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KW - FRANCE

KW - EPIDEMIOLOGY

KW - LEUKEMIA

KW - BLOOD

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