Maternal Metabolism and Vascular Adaptation in Pregnancy: The PPAR Link

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Abstract

Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalTrends in Endocrinology and Metabolism
Volume28
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

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