TY - JOUR
T1 - Maternal Metabolism and Vascular Adaptation in Pregnancy
T2 - The PPAR Link
AU - Ganss, Ruth
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.
AB - Current therapies for pregnancy-related hypertension and its complications remain inadequate, although an increasing role for maternal susceptibility is becoming evident. Systemic vascular dysfunction in response to imbalances in angiogenic, inflammatory, and constricting factors is implicated in the pathogenesis of gestational hypertension, and growing evidence now links these factors with maternal metabolism. In particular, the crucial role of peroxisome proliferator-activated receptors (PPARs) in maternal vascular adaptation provides further insights into how obesity and gestational diabetes may be linked to pregnancy-induced hypertension and preeclampsia. This is especially important given the rapidly growing prevalence of obesity during pregnancy, and highlights a new approach to treat pregnancy-related hypertension and its complications.
KW - blood vessel
KW - metabolism
KW - PPAR
KW - preeclampsia
KW - pregnancy
KW - RGS5
UR - http://www.scopus.com/inward/record.url?scp=85003023627&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2016.09.004
DO - 10.1016/j.tem.2016.09.004
M3 - Review article
C2 - 27789100
AN - SCOPUS:85003023627
SN - 1043-2760
VL - 28
SP - 73
EP - 84
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 1
ER -