Maternal genetic variants of IL4/IL13 pathway genes on IgE with "Western or eastern environments/lifestyles"

G. Zhang, Siew-Kim Khoo, M.J. Mäkelä, Pierre Candelaria, Catherine Hayden, L.C. Von Hertzen, T.K.M. Laatikainen, E.A. Vartiainen, Jack Goldblatt, T.M.K. Haahtela, Peter Le Souef

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Purpose: We investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the "Western or Eastern lifestyles/environments" on IgE in Karelian children. Methods: This study included 609 children and their mothers. Total IgE levels in children and mothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children. Results: The maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelian population (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly (P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian children of mothers who were AG heterozygotes or AA homozygotes. After accounting for children's genotypes, we observed interactive effects on children's IgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with "Western or Eastern" lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra 50 SNP was significant. Conclusion: Maternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in school children that were independent of the children's genetic effects. These effects differ in "Western or Eastern" environments. © Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology.
    Original languageEnglish
    Pages (from-to)350-356
    JournalAllergy, Asthma and Immunology Research
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - Jul 2014

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