Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Gemma C. Sharp; Lucas A. Salas; Claire Monnereau; Catherine Allard; Paul Yousefi; Todd M. Everson; Jon Bohlin; Zongli Xu; Rae-Chi Huang; Sarah E. Reese; Cheng-Jian Xu; Nour Baiz; Cathrine Hoyo; Golareh Agha; Ritu Roy; John W. Holloway; Akram Ghantous; Simon K. Merid; Kelly M. Bakulski; Leanne K. Kupers; Hongmei Zhang; Rebecca C. Richmond; Christian M. Page; Liesbeth Duijts; Rolv T. Lie; Phillip E. Melton; Judith M. Vonk; Ellen A. Nohr; ClarLynda Williams-DeVane; Karen Huen; Sheryl L. Rifas-Shiman; Carlos Ruiz-Arenas; Semira Gonseth; Faisal I. Rezwan; Zdenko Herceg; Sandra Ekstrom; Lisa Croen; Fahimeh Falahi; Patrice Perron; Margaret R. Karagas; Bilal M. Quraishi; Matthew Suderman; Maria C. Magnus; Vincent W. V. Jaddoe; Jack A. Taylor; Denise Anderson; Shanshan Zhao; Henriette A. Smit; Michele J. Josey; Asa Bradman; Andrea A. Baccarelli; Mariona Bustamante; Siri E. Haberg; Goran Pershagen; Irva Hertz-Picciotto; Craig Newschaffer; Eva Corpeleijn; Luigi Bouchard; Debbie A. Lawlor; Rachel L. Maguire; Lisa F. Barcellos; George Davey Smith; Brenda Eskenazi; Wilfried Karmaus; Carmen J. Marsit; Marie-France Hivert; Harold Snieder; M. Daniele Fallin; Erik Melen; Monica C. Munthe-Kaas; Hasan Arshad; Joseph L. Wiemels; Isabella Annesi-Maesano; Martine Vrijheid; Emily Oken; Nina Holland; Susan K. Murphy; Thorkild I. A. Sorensen; Gerard H. Koppelman; John P. Newnham; Allen J. Wilcox; Wenche Nystad; Stephanie J. London; Janine F. Felix; Caroline L. Relton

doi:10.1093/hmg/ddx290

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Gemma C. Sharp
, Lucas A. Salas
, Claire Monnereau
, Catherine Allard
, Paul Yousefi
, Todd M. Everson
, Jon Bohlin
, Zongli Xu
, Rae-Chi Huang
, Sarah E. Reese
, Cheng-Jian Xu
, Nour Baiz
, Cathrine Hoyo
, Golareh Agha
, Ritu Roy
, John W. Holloway
, Akram Ghantous
, Simon K. Merid
, Kelly M. Bakulski
, Leanne K. Kupers

Hongmei Zhang, Rebecca C. Richmond, Christian M. Page, Liesbeth Duijts, Rolv T. Lie, Phillip E. Melton, Judith M. Vonk, Ellen A. Nohr, ClarLynda Williams-DeVane, Karen Huen, Sheryl L. Rifas-Shiman, Carlos Ruiz-Arenas, Semira Gonseth, Faisal I. Rezwan, Zdenko Herceg, Sandra Ekstrom, Lisa Croen, Fahimeh Falahi, Patrice Perron, Margaret R. Karagas, Bilal M. Quraishi, Matthew Suderman, Maria C. Magnus, Vincent W. V. Jaddoe, Jack A. Taylor, Denise Anderson, Shanshan Zhao, Henriette A. Smit, Michele J. Josey, Asa Bradman, Andrea A. Baccarelli, Mariona Bustamante, Siri E. Haberg, Goran Pershagen, Irva Hertz-Picciotto, Craig Newschaffer, Eva Corpeleijn, Luigi Bouchard, Debbie A. Lawlor, Rachel L. Maguire, Lisa F. Barcellos, George Davey Smith, Brenda Eskenazi, Wilfried Karmaus, Carmen J. Marsit, Marie-France Hivert, Harold Snieder, M. Daniele Fallin, Erik Melen, Monica C. Munthe-Kaas, Hasan Arshad, Joseph L. Wiemels, Isabella Annesi-Maesano, Martine Vrijheid, Emily Oken, Nina Holland, Susan K. Murphy, Thorkild I. A. Sorensen, Gerard H. Koppelman, John P. Newnham, Allen J. Wilcox, Wenche Nystad, Stephanie J. London, Janine F. Felix, Caroline L. Relton

Research output: Contribution to journal › Article › peer-review

196 Citations (Scopus)

Abstract

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (

Original language	English
Pages (from-to)	4067-4085
Number of pages	19
Journal	Human Molecular Genetics
Volume	26
Issue number	20
DOIs	https://doi.org/10.1093/hmg/ddx290
Publication status	Published - 15 Oct 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/hmg/ddx290

Cite this

Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., Bohlin, J., Xu, Z., Huang, R.-C., Reese, S. E., Xu, C.-J., Baiz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J. W., Ghantous, A., Merid, S. K., Bakulski, K. M., ... Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067-4085. https://doi.org/10.1093/hmg/ddx290

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title = "Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium",

abstract = "Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (",

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author = "Sharp, \{Gemma C.\} and Salas, \{Lucas A.\} and Claire Monnereau and Catherine Allard and Paul Yousefi and Everson, \{Todd M.\} and Jon Bohlin and Zongli Xu and Rae-Chi Huang and Reese, \{Sarah E.\} and Cheng-Jian Xu and Nour Baiz and Cathrine Hoyo and Golareh Agha and Ritu Roy and Holloway, \{John W.\} and Akram Ghantous and Merid, \{Simon K.\} and Bakulski, \{Kelly M.\} and Kupers, \{Leanne K.\} and Hongmei Zhang and Richmond, \{Rebecca C.\} and Page, \{Christian M.\} and Liesbeth Duijts and Lie, \{Rolv T.\} and Melton, \{Phillip E.\} and Vonk, \{Judith M.\} and Nohr, \{Ellen A.\} and ClarLynda Williams-DeVane and Karen Huen and Rifas-Shiman, \{Sheryl L.\} and Carlos Ruiz-Arenas and Semira Gonseth and Rezwan, \{Faisal I.\} and Zdenko Herceg and Sandra Ekstrom and Lisa Croen and Fahimeh Falahi and Patrice Perron and Karagas, \{Margaret R.\} and Quraishi, \{Bilal M.\} and Matthew Suderman and Magnus, \{Maria C.\} and Jaddoe, \{Vincent W. V.\} and Taylor, \{Jack A.\} and Denise Anderson and Shanshan Zhao and Smit, \{Henriette A.\} and Josey, \{Michele J.\} and Asa Bradman and Baccarelli, \{Andrea A.\} and Mariona Bustamante and Haberg, \{Siri E.\} and Goran Pershagen and Irva Hertz-Picciotto and Craig Newschaffer and Eva Corpeleijn and Luigi Bouchard and Lawlor, \{Debbie A.\} and Maguire, \{Rachel L.\} and Barcellos, \{Lisa F.\} and Smith, \{George Davey\} and Brenda Eskenazi and Wilfried Karmaus and Marsit, \{Carmen J.\} and Marie-France Hivert and Harold Snieder and Fallin, \{M. Daniele\} and Erik Melen and Munthe-Kaas, \{Monica C.\} and Hasan Arshad and Wiemels, \{Joseph L.\} and Isabella Annesi-Maesano and Martine Vrijheid and Emily Oken and Nina Holland and Murphy, \{Susan K.\} and Sorensen, \{Thorkild I. A.\} and Koppelman, \{Gerard H.\} and Newnham, \{John P.\} and Wilcox, \{Allen J.\} and Wenche Nystad and London, \{Stephanie J.\} and Felix, \{Janine F.\} and Relton, \{Caroline L.\}",

year = "2017",

month = oct,

day = "15",

doi = "10.1093/hmg/ddx290",

language = "English",

volume = "26",

pages = "4067--4085",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "20",

}

Sharp, GC, Salas, LA, Monnereau, C, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, Z, Huang, R-C, Reese, SE, Xu, C-J, Baiz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Kupers, LK, Zhang, H, Richmond, RC, Page, CM, Duijts, L, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekstrom, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, VWV, Taylor, JA, Anderson, D, Zhao, S, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Haberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Smith, GD, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, M-F, Snieder, H, Fallin, MD, Melen, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sorensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, JF & Relton, CL 2017, 'Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium', Human Molecular Genetics, vol. 26, no. 20, pp. 4067-4085. https://doi.org/10.1093/hmg/ddx290

TY - JOUR

T1 - Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation

T2 - findings from the pregnancy and childhood epigenetics (PACE) consortium

AU - Sharp, Gemma C.

AU - Salas, Lucas A.

AU - Monnereau, Claire

AU - Allard, Catherine

AU - Yousefi, Paul

AU - Everson, Todd M.

AU - Bohlin, Jon

AU - Xu, Zongli

AU - Huang, Rae-Chi

AU - Reese, Sarah E.

AU - Xu, Cheng-Jian

AU - Baiz, Nour

AU - Hoyo, Cathrine

AU - Agha, Golareh

AU - Roy, Ritu

AU - Holloway, John W.

AU - Ghantous, Akram

AU - Merid, Simon K.

AU - Bakulski, Kelly M.

AU - Kupers, Leanne K.

AU - Zhang, Hongmei

AU - Richmond, Rebecca C.

AU - Page, Christian M.

AU - Duijts, Liesbeth

AU - Lie, Rolv T.

AU - Melton, Phillip E.

AU - Vonk, Judith M.

AU - Nohr, Ellen A.

AU - Williams-DeVane, ClarLynda

AU - Huen, Karen

AU - Rifas-Shiman, Sheryl L.

AU - Ruiz-Arenas, Carlos

AU - Gonseth, Semira

AU - Rezwan, Faisal I.

AU - Herceg, Zdenko

AU - Ekstrom, Sandra

AU - Croen, Lisa

AU - Falahi, Fahimeh

AU - Perron, Patrice

AU - Karagas, Margaret R.

AU - Quraishi, Bilal M.

AU - Suderman, Matthew

AU - Magnus, Maria C.

AU - Jaddoe, Vincent W. V.

AU - Taylor, Jack A.

AU - Anderson, Denise

AU - Zhao, Shanshan

AU - Smit, Henriette A.

AU - Josey, Michele J.

AU - Bradman, Asa

AU - Baccarelli, Andrea A.

AU - Bustamante, Mariona

AU - Haberg, Siri E.

AU - Pershagen, Goran

AU - Hertz-Picciotto, Irva

AU - Newschaffer, Craig

AU - Corpeleijn, Eva

AU - Bouchard, Luigi

AU - Lawlor, Debbie A.

AU - Maguire, Rachel L.

AU - Barcellos, Lisa F.

AU - Smith, George Davey

AU - Eskenazi, Brenda

AU - Karmaus, Wilfried

AU - Marsit, Carmen J.

AU - Hivert, Marie-France

AU - Snieder, Harold

AU - Fallin, M. Daniele

AU - Melen, Erik

AU - Munthe-Kaas, Monica C.

AU - Arshad, Hasan

AU - Wiemels, Joseph L.

AU - Annesi-Maesano, Isabella

AU - Vrijheid, Martine

AU - Oken, Emily

AU - Holland, Nina

AU - Murphy, Susan K.

AU - Sorensen, Thorkild I. A.

AU - Koppelman, Gerard H.

AU - Newnham, John P.

AU - Wilcox, Allen J.

AU - Nystad, Wenche

AU - London, Stephanie J.

AU - Felix, Janine F.

AU - Relton, Caroline L.

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (

AB - Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (

KW - BODY-MASS INDEX

KW - GESTATIONAL WEIGHT-GAIN

KW - CORD BLOOD

KW - NORWEGIAN MOTHER

KW - GENETIC-VARIANTS

KW - CHILDREN ALSPAC

KW - COHORT PROFILE

KW - GENERATION R

KW - BIRTH COHORT

KW - EARLY-LIFE

U2 - 10.1093/hmg/ddx290

DO - 10.1093/hmg/ddx290

M3 - Article

C2 - 29016858

SN - 0964-6906

VL - 26

SP - 4067

EP - 4085

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 20

ER -

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Abstract

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