Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Gemma C. Sharp, Lucas A. Salas, Claire Monnereau, Catherine Allard, Paul Yousefi, Todd M. Everson, Jon Bohlin, Zongli Xu, Rae-Chi Huang, Sarah E. Reese, Cheng-Jian Xu, Nour Baiz, Cathrine Hoyo, Golareh Agha, Ritu Roy, John W. Holloway, Akram Ghantous, Simon K. Merid, Kelly M. Bakulski, Leanne K. KupersHongmei Zhang, Rebecca C. Richmond, Christian M. Page, Liesbeth Duijts, Rolv T. Lie, Phillip E. Melton, Judith M. Vonk, Ellen A. Nohr, ClarLynda Williams-DeVane, Karen Huen, Sheryl L. Rifas-Shiman, Carlos Ruiz-Arenas, Semira Gonseth, Faisal I. Rezwan, Zdenko Herceg, Sandra Ekstrom, Lisa Croen, Fahimeh Falahi, Patrice Perron, Margaret R. Karagas, Bilal M. Quraishi, Matthew Suderman, Maria C. Magnus, Vincent W. V. Jaddoe, Jack A. Taylor, Denise Anderson, Shanshan Zhao, Henriette A. Smit, Michele J. Josey, Asa Bradman, Andrea A. Baccarelli, Mariona Bustamante, Siri E. Haberg, Goran Pershagen, Irva Hertz-Picciotto, Craig Newschaffer, Eva Corpeleijn, Luigi Bouchard, Debbie A. Lawlor, Rachel L. Maguire, Lisa F. Barcellos, George Davey Smith, Brenda Eskenazi, Wilfried Karmaus, Carmen J. Marsit, Marie-France Hivert, Harold Snieder, M. Daniele Fallin, Erik Melen, Monica C. Munthe-Kaas, Hasan Arshad, Joseph L. Wiemels, Isabella Annesi-Maesano, Martine Vrijheid, Emily Oken, Nina Holland, Susan K. Murphy, Thorkild I. A. Sorensen, Gerard H. Koppelman, John P. Newnham, Allen J. Wilcox, Wenche Nystad, Stephanie J. London, Janine F. Felix, Caroline L. Relton

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Abstract

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (

Original languageEnglish
Pages (from-to)4067-4085
Number of pages19
JournalHuman Molecular Genetics
Volume26
Issue number20
DOIs
Publication statusPublished - 15 Oct 2017

Cite this

Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., Bohlin, J., Xu, Z., Huang, R-C., Reese, S. E., Xu, C-J., Baiz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J. W., Ghantous, A., Merid, S. K., Bakulski, K. M., ... Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067-4085. https://doi.org/10.1093/hmg/ddx290