Maternal Adaptation to Pregnancy: Altered Circadian Rhythms of Clock Genes in the Hypothalamus and Metabolic Tissues

Michaela Debra Wharfe

    Research output: ThesisDoctoral Thesis

    227 Downloads (Pure)


    Maternal physiological adaptations are crucial for pregnancy success to ensure that fetal and placental demands are met whilst maintaining maternal homeostasis. As whole body homeostasis is intimately linked to the circadian system via the rhythmic expression of clock genes, major physiological adaptations in pregnancy likely involve marked shifts in maternal circadian function. Hypothalamic, hepatic and adipose clock gene and metabolic gene expression was examined throughout gestation in C57BI/6J mice across 24-hour periods (0800, 1200, 1600, 2000, 0000, 0400). Overall, these studies demonstrate that substantial pregnancy-induced changes occur in the circadian oscillations of clock genes and metabolic genes throughout mouse pregnancy.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date29 Sep 2016
    Publication statusUnpublished - 2016


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