Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

Robert Mclaughlin; Loretta Scolaro; P. Robbins; Christobel Saunders; S.L. Jacques; David Sampson; Guang-Zhong Yang; David Hawkes; Daniel Rueckert; Alison Noble; Chris Taylor

doi:10.1007/978-3-642-04271-3_80

Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

Robert Mclaughlin, Loretta Scolaro, P. Robbins, Christobel Saunders, S.L. Jacques, David Sampson, Guang-Zhong Yang (Editor), David Hawkes (Editor), Daniel Rueckert (Editor), Alison Noble (Editor), Chris Taylor (Editor)

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19 Citations (Scopus)

Abstract

The lymphatic system is a common route for the spread of cancer andthe identification of lymph node metastases is a key task during cancer surgery.This paper demonstrates the use of optical coherence tomography to constructparametric images of lymph nodes. It describes a method to automatically estimatethe optical attenuation coefficient of tissue. By mapping the opticalattenuation coefficient at each location in the scan, it is possible to construct aparametric image indicating variations in tissue type. The algorithm is appliedto ex vivo samples of human axillary lymph nodes and validated against a histologicalgold standard. Results are shown illustrating the variation in opticalproperties between cancerous and healthy tissue.

Original language	English
Pages (from-to)	657-664
Journal	Lecture Notes in Computer Science
Volume	5762
Issue number	2
DOIs	https://doi.org/10.1007/978-3-642-04271-3_80
Publication status	Published - 2009

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Mclaughlin, R., Scolaro, L., Robbins, P., Saunders, C., Jacques, S. L., Sampson, D., Yang, G.-Z. (Ed.), Hawkes, D. (Ed.), Rueckert, D. (Ed.), Noble, A. (Ed.), & Taylor, C. (Ed.) (2009). Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography. Lecture Notes in Computer Science, 5762(2), 657-664. https://doi.org/10.1007/978-3-642-04271-3_80

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title = "Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography",

abstract = "The lymphatic system is a common route for the spread of cancer andthe identification of lymph node metastases is a key task during cancer surgery.This paper demonstrates the use of optical coherence tomography to constructparametric images of lymph nodes. It describes a method to automatically estimatethe optical attenuation coefficient of tissue. By mapping the opticalattenuation coefficient at each location in the scan, it is possible to construct aparametric image indicating variations in tissue type. The algorithm is appliedto ex vivo samples of human axillary lymph nodes and validated against a histologicalgold standard. Results are shown illustrating the variation in opticalproperties between cancerous and healthy tissue.",

author = "Robert Mclaughlin and Loretta Scolaro and P. Robbins and Christobel Saunders and S.L. Jacques and David Sampson and Guang-Zhong Yang and David Hawkes and Daniel Rueckert and Alison Noble and Chris Taylor",

year = "2009",

doi = "10.1007/978-3-642-04271-3_80",

language = "English",

volume = "5762",

pages = "657--664",

journal = "Lecture Notes in Computer Science",

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Mclaughlin, R, Scolaro, L, Robbins, P, Saunders, C, Jacques, SL, Sampson, D, Yang, G-Z (ed.), Hawkes, D (ed.), Rueckert, D (ed.), Noble, A (ed.) & Taylor, C (ed.) 2009, 'Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography', Lecture Notes in Computer Science, vol. 5762, no. 2, pp. 657-664. https://doi.org/10.1007/978-3-642-04271-3_80

TY - JOUR

T1 - Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

AU - Mclaughlin, Robert

AU - Scolaro, Loretta

AU - Robbins, P.

AU - Saunders, Christobel

AU - Jacques, S.L.

AU - Sampson, David

A2 - Yang, Guang-Zhong

A2 - Hawkes, David

A2 - Rueckert, Daniel

A2 - Noble, Alison

A2 - Taylor, Chris

PY - 2009

Y1 - 2009

N2 - The lymphatic system is a common route for the spread of cancer andthe identification of lymph node metastases is a key task during cancer surgery.This paper demonstrates the use of optical coherence tomography to constructparametric images of lymph nodes. It describes a method to automatically estimatethe optical attenuation coefficient of tissue. By mapping the opticalattenuation coefficient at each location in the scan, it is possible to construct aparametric image indicating variations in tissue type. The algorithm is appliedto ex vivo samples of human axillary lymph nodes and validated against a histologicalgold standard. Results are shown illustrating the variation in opticalproperties between cancerous and healthy tissue.

AB - The lymphatic system is a common route for the spread of cancer andthe identification of lymph node metastases is a key task during cancer surgery.This paper demonstrates the use of optical coherence tomography to constructparametric images of lymph nodes. It describes a method to automatically estimatethe optical attenuation coefficient of tissue. By mapping the opticalattenuation coefficient at each location in the scan, it is possible to construct aparametric image indicating variations in tissue type. The algorithm is appliedto ex vivo samples of human axillary lymph nodes and validated against a histologicalgold standard. Results are shown illustrating the variation in opticalproperties between cancerous and healthy tissue.

U2 - 10.1007/978-3-642-04271-3_80

DO - 10.1007/978-3-642-04271-3_80

M3 - Article

SN - 0302-9743

VL - 5762

SP - 657

EP - 664

JO - Lecture Notes in Computer Science

JF - Lecture Notes in Computer Science

IS - 2

ER -

Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

Abstract

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