Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes

Michel Haïssaguerre, Fabrice Extramiana, Mélèze Hocini, Bruno Cauchemez, Pierre Jaïs, Jose Angel Cabrera, Geronimo Farre, Antoine Leenhardt, Prashanthan Sanders, Christophe Scavée, Li Fern Hsu, Rukshen Weerasooriya, Dipen C. Shah, Robert Frank, Philippe Maury, Marc Delay, Stéphane Garrigue, Jacques Clémenty

Research output: Contribution to journalArticlepeer-review

433 Citations (Scopus)


Background - The long-QT and Brugada syndromes are important substrates of malignant ventricular arrhythmia. The feasibility of mapping and ablation of ventricular arrhythmias in these conditions has not been reported. Methods and Results - Seven patients (4 men; age, 38±7 years; 4 with long-QT and 3 with Brugada syndrome) with episodes of ventricular fibrillation or polymorphic ventricular tachycardia and frequent isolated or repetitive premature beats were studied. These premature beats were observed to trigger ventricular arrhythmias and were localized by mapping the earliest endocardial activity. In 4 patients, premature beats originated from the peripheral right (1 Brugada) or left (3 long-QT) Purkinje conducting system and were associated with variable Purkinje-to-muscle conduction times (30 to 110 ms). In the remaining 3 patients, premature beats originated from the right ventricular outflow tract, being 25 to 40 ms ahead of the QRS. The accuracy of mapping was confirmed by acute elimination of premature beats after 12±6 minutes of radiofrequency applications. During a follow-up of 17±17 months using ambulatory monitoring and defibrillator memory interrogation, no patients had recurrence of symptomatic ventricular arrhythmia but 1 had persistent premature beats. Conclusion - Triggers from the Purkinje arborization or the right ventricular outflow tract have a crucial role in initiating ventricular fibrillation associated with the long-QT and Brugada syndromes. These can be eliminated by focal radiofrequency ablation.
Original languageEnglish
Pages (from-to)925-928
Number of pages4
Issue number8
Publication statusPublished - 26 Aug 2003


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