Manipulation of frequency analysis in the cochlear ganglion of the guinea pig

Donald Robertson, Geoffrey A. Manley

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86 Citations (Scopus)


1. Recordings of extracellular activity were obtained from single cells in the spiral ganglion of the basal turn of the guinea pig cochlea. 2. The spatial distribution of characteristic frequencies of cells in the ganglion was consistent with published data on the location of displacement maxima on the basilar membrane. 3. Large variations in the sharpness of single cell tuning curves were seen between animals. These variations were closely linked to sensitivity differences. 4. The tuning curves of single cells could be made less sharp by slowing the rate of artificial ventilation. These tuning curve changes were reversible and intimately associated with alterations in sensitivity and spontaneous activity. 5. The data point either to the presence of a mechanical non-linearity, or a physiologically vulnerable second filter, as the explanation for the sharpness of neural tuning curves in cochlear nerve fibres.

Original languageEnglish
Pages (from-to)363-375
Number of pages13
JournalJournal of Comparative Physiology
Issue number4
Publication statusPublished - 1 Dec 1974
Externally publishedYes

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J. Comp. Physiol. Cited By :85 Export Date: 1 July 2019 Article CODEN: JCPAD Correspondence Address: Robertson, D.; Department of Biology, McGill University, Montreal, P. Q., Canada References: DeBoer, E., Initiation of nerve impulses in the inner ear (1969) Proc. kon. ned. Akad. Wet, 72, pp. 129-151; Evans, E. F.: Narrow tuning of the responses of the cochlear nerve fibres emanating from the exposed hasilar membrane. J. Physiol. (Lond.) 208, 75–76 P (1970); Evans, E.F., The frequency response and other properties of single fibres in the guinea pig cochlear nerve (1972) J. Physiol. (Lond.), 226, pp. 263-287; Prank, K., Becker, M.C., Microelectrodes for recording and stimulation (1964) Physical techniques in biological research, vol. 5, , W. L., Nastuk, Acad. Press, New York; Johnstone, B.M., Taylor, K.J., Boyle, A.J., Mechanics of the guinea pig cochlea (1970) The Journal of the Acoustical Society of America, 47, pp. 504-509; Johnstone, B. M., Yates, G.: Basilar membrane tuning. Proc. 85th Meeting Acoust. Soc. Amer. (1973); Kiang, N.Y.S., (1965) Discharge patterns of single fibres in the cat's auditory nerve, , M.I.T. Press, Cambridge (Mass.); Kiang, N.Y.S., Moxon, E.C., Levine, R.A., Auditory nerve activity in cats with normal and abnormal cochleas (1970) Sensorineural Hearing Loss, pp. 241-273. , G., Wolstenholme, K., Knight, Churchill, London; Moller, A.R., Studies of the damped oscillatory response of the auditory frequency analyzer (1970) Acta physiol. scand., 78, pp. 299-314; Nomoto, M., Suga, N., Katsuki, Y., Discharge patterns and inhibition of primary auditory nerve fibres in the monkey (1964) J. Neurophysiol., 27, pp. 768-787; Rhode, W.S., Observations of the vibration of the basilar membrane of squirrel monkeys using the Mössbauer technique (1971) The Journal of the Acoustical Society of America, 49, pp. 1218-1231; Smoorenburg, G.F., Combination tones and their origin (1972) The Journal of the Acoustical Society of America, 52, pp. 615-632; Tonndorf, J., Time/frequency analysis along the partition of cochlear models (1962) The Journal of the Acoustical Society of America, 34, pp. 1337-1350; Wilson, J. P., Johnstone, J. R.: Capacitive probe measures of basilar membrane vibration. Symp. on Hearing Theory, LPO Eindhoven (1972)UR -

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