Manipulating expression of the gene PTEN in cancer and the central nervous system with genetic and epigenetic editing

Colette Moses

Research output: ThesisDoctoral Thesis

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Abstract

Genetic or epigenetic loss of phosphatase and tensin homolog (PTEN) contributes to the initiation, progression and drug resistance of many human cancers. However, PTEN is strongly expressed in central nervous system (CNS) neurons, and inhibits their ability to survive and regenerate axons to restore functional connections after traumatic brain or spinal cord injury, stroke or neurodegenerative disease. This research developed genetic and epigenetic editing tools to restore expression of PTEN in cancer cells where the gene was transcriptionally repressed or mutated, and to silence PTEN expression in CNS neurons, with potential future applications for treatment of cancer and CNS regenerative failure.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date25 Oct 2018
DOIs
Publication statusUnpublished - 2018

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