Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw; Tristan Clemons; Di Wei Ho; L. Gutiérrez; F.J./. Lázaro; Mike House; Tim St. Pierre; Mark Fear; Fiona Wood; Killugudi Swaminatha Iyer

doi:10.1039/c4nr06594h

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw, Tristan Clemons, Di Wei Ho, L. Gutiérrez, F.J./. Lázaro, Mike House, Tim St. Pierre, Mark Fear, Fiona Wood, Killugudi Swaminatha Iyer

School of Molecular Sciences

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Abstract

This journal is © The Royal Society of Chemistry 2015. This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

Original language	English
Pages (from-to)	4884-4889
Journal	Nanoscale
Volume	7
Issue number	11
Early online date	5 Feb 2015
DOIs	https://doi.org/10.1039/c4nr06594h
Publication status	Published - 21 Mar 2015

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abstract = "This journal is {\textcopyright} The Royal Society of Chemistry 2015. This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.",

author = "Michael Bradshaw and Tristan Clemons and Ho, {Di Wei} and L. Guti{\'e}rrez and F.J./. L{\'a}zaro and Mike House and {St. Pierre}, Tim and Mark Fear and Fiona Wood and {Swaminatha Iyer}, Killugudi",

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AU - Bradshaw, Michael

AU - Clemons, Tristan

AU - Ho, Di Wei

AU - Gutiérrez, L.

AU - Lázaro, F.J./.

AU - House, Mike

AU - St. Pierre, Tim

AU - Fear, Mark

AU - Wood, Fiona

AU - Swaminatha Iyer, Killugudi

PY - 2015/3/21

Y1 - 2015/3/21

N2 - This journal is © The Royal Society of Chemistry 2015. This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

AB - This journal is © The Royal Society of Chemistry 2015. This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

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DO - 10.1039/c4nr06594h

M3 - Article

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SP - 4884

EP - 4889

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

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ER -

Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Abstract

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