Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Michael Bradshaw, Tristan Clemons, Di Wei Ho, L. Gutiérrez, F.J./. Lázaro, Mike House, Tim St. Pierre, Mark Fear, Fiona Wood, Killugudi Swaminatha Iyer

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
365 Downloads (Pure)

Abstract

This journal is © The Royal Society of Chemistry 2015. This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.
Original languageEnglish
Pages (from-to)4884-4889
JournalNanoscale
Volume7
Issue number11
Early online date5 Feb 2015
DOIs
Publication statusPublished - 21 Mar 2015

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