Manipulating and elucidating mitochondrial gene expression with engineered proteins

Christopher P. Wallis, Louis H. Scott, Aleksandra Filipovska, Oliver Rackham

Research output: Contribution to journalArticle

2 Citations (Scopus)


Many conventional, modern genome engineering tools cannot be used to study mitochondrial genetics due to the unusual structure and physiology of the mitochondrial genome. Here, we review a number of newly developed, synthetic biology-based approaches for altering levels of mutant mammalian mitochondrial DNA and mitochondrial RNAs, including transcription activator-like effector nucleases, zinc finger nucleases and engineered RNA-binding proteins. These approaches allow researchers to manipulate and visualize mitochondrial processes and may provide future therapeutics.

Original languageEnglish
Article number20190185
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1790
Publication statusPublished - 1 Jan 2020

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