TY - JOUR
T1 - Management of indolent B-cell Lymphomas
T2 - A review of approved and emerging targeted therapies
AU - Smyth, Elizabeth
AU - Cheah, Chan Y.
AU - Seymour, John F.
PY - 2023/2
Y1 - 2023/2
N2 - The indolent B-cell non-Hodgkin lymphomas (B-NHL) comprise a heterogenous group of lymphoproliferative disorders characterized by slow growth kinetics and a relapsing/remitting course. Management has, until recently, been uniform across all indolent B-NHL subtypes. Improving insight into pathophysiological and molecular features of each disease has led to development of several targeted therapies. Consequently, each subtype must now be considered an individual entity. In this review, we consider the three commonest indolent B-NHLs: follicular lymphoma, marginal zone lymphoma and Waldenstrom's macroglobulinemia and review in detail the data on approved and emerging targeted therapeutic agents for each B-NHL subtype.
AB - The indolent B-cell non-Hodgkin lymphomas (B-NHL) comprise a heterogenous group of lymphoproliferative disorders characterized by slow growth kinetics and a relapsing/remitting course. Management has, until recently, been uniform across all indolent B-NHL subtypes. Improving insight into pathophysiological and molecular features of each disease has led to development of several targeted therapies. Consequently, each subtype must now be considered an individual entity. In this review, we consider the three commonest indolent B-NHLs: follicular lymphoma, marginal zone lymphoma and Waldenstrom's macroglobulinemia and review in detail the data on approved and emerging targeted therapeutic agents for each B-NHL subtype.
KW - Follicular lymphoma
KW - Marginal zone lymphoma
KW - Targeted therapies
KW - Waldenstrom's macroglobulinemia
UR - http://www.scopus.com/inward/record.url?scp=85146218173&partnerID=8YFLogxK
U2 - 10.1016/j.ctrv.2023.102510
DO - 10.1016/j.ctrv.2023.102510
M3 - Review article
C2 - 36634434
AN - SCOPUS:85146218173
SN - 0305-7372
VL - 113
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
M1 - 102510
ER -