Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

A. Burton, G. Byrnes, Jennifer Stone, R.M. Tamimi, J. Heine, C. Vachon, V. Ozmen, A. Pereira, M.L. Garmendia, C. Scott, J.H. Hipwell, C. Dickens, J. Schüz, M.E. Aribal, K. Bertrand, A. Kwong, G.G. Giles, J. Hopper, B. Pérez Gómez, M. PollánS.H. Teo, S. Mariapun, N.A.M. Taib, M. Lajous, R. Lopez-Riduara, M. Rice, I. Romieu, A.A. Flugelman, G. Ursin, S. Qureshi, H. Ma, E. Lee, R. Sirous, M. Sirous, J.W. Lee, J. Kim, D. Salem, R. Kamal, M. Hartman, H. Miao, K.S. Chia, C. Nagata, S. Vinayak, R. Ndumia, C.H. Van Gils, J.O.P. Wanders, B. Peplonska, A. Bukowska, S. Allen, S. Vinnicombe, S. Moss, A.M. Chiarelli, L. Linton, G. Maskarinec, M.J. Yaffe, N.F. Boyd, I. Dos-Santos-Silva, V.A. Mccormack

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Abstract

© 2016 The Author(s).Background: Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/digital) and digital image format (raw/processed). We aimed to examine differences in MD assessed on these image types. Methods: We obtained 1294 pairs of images saved in both raw and processed formats from Hologic and General Electric (GE) direct digital systems and a Fuji computed radiography (CR) system, and 128 screen-film and processed CR-digital pairs from consecutive screening rounds. Four readers performed Cumulus-based MD measurements (n=3441), with each image pair read by the same reader. Multi-level models of square-root percent MD were fitted, with a random intercept for woman, to estimate processed-raw MD differences. Results: Breast area did not differ in processed images compared with that in raw images, but the percent MD was higher, due to a larger dense area (median 28.5 and 25.4cm2 respectively, mean √dense area difference 0.44cm (95% CI: 0.36, 0.52)). This difference in √dense area was significant for direct digital systems (Hologic 0.50cm (95% CI: 0.39, 0.61), GE 0.56cm (95% CI: 0.42, 0.69)) but not for Fuji CR (0.06cm (95% CI: 0.10, 0.23)). Additionally, within each system, reader-specific differences varied in magnitude and direction (p
Original languageEnglish
Pages (from-to)e130
JournalBreast Cancer Research
Volume18
Issue number1
DOIs
Publication statusPublished - 2016

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