Malignant pleural mesothelioma: an update on diagnosis and treatment options

S. Kondola, D. Manners, Anna Nowak

    Research output: Contribution to journalReview articlepeer-review

    41 Citations (Scopus)


    Malignant pleural mesothelioma (MPM) represents a significant diagnostic and therapeutic challenge and is almost always a fatal disease. Imaging abnormalities are common, but have a limited role in distinguishing mesothelioma from metastatic pleural disease. Similarly, minimally invasive biomarkers have shown promise but also have limitations in the diagnosis of mesothelioma. In experienced centers, cytology and immunohistochemistry are now sufficient to diagnose the epithelioid subtype of mesothelioma, which can reduce the need for more invasive diagnostic investigations. Prognosis of MPM is modestly impacted by oncological treatments. Chemotherapy with cisplatin and pemetrexed is considered the standard of care, though the addition of bevacizumab to the platinum doublet may be the new standard of care. New targeted therapies have demonstrated some promise and are being addressed in clinical trials. This review focuses on the current data on the diagnostic and therapeutic issues of MPM.
    Original languageEnglish
    Pages (from-to)275-288
    Issue number3
    Publication statusPublished - Jun 2016


    Dive into the research topics of 'Malignant pleural mesothelioma: an update on diagnosis and treatment options'. Together they form a unique fingerprint.

    Cite this