Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds

Megan Heffernan, Gavin Andrews, Maria A. Fiatarone Singh, Michael Valenzuela, Kaarin J. Anstey, Anthony J. Maeder, John McNeil, Louisa Jorm, Nicola T. Lautenschlager, Perminder S. Sachdev, Jeewani A. Ginige, Megan J. Hobbs, Christos Boulamatsis, Tiffany Chau, Lynne Cobiac, Kay L. Cox, Kenneth Daniel, Victoria M. Flood, Yareni Guerrero, Jane Gunn & 10 others Nidhi Jain, Nicole A. Kochan, Amit Lampit, Yorgi Mavros, Jacinda Meiklejohn, Yian Noble, Fiona O'Leary, Sue Radd-Vagenas, Courtney C. Walton, Henry Brodaty

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.

Original languageEnglish
Pages (from-to)S221-S237
JournalJournal of Alzheimer's Disease
Volume70
Issue numbers1
DOIs
Publication statusPublished - 1 Jan 2019

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Independent Living
Randomized Controlled Trials
Health
Brain
Dementia
Mental Health
South Australia
New South Wales
Internet
Cognitive Dysfunction
Life Style

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Heffernan, Megan ; Andrews, Gavin ; Fiatarone Singh, Maria A. ; Valenzuela, Michael ; Anstey, Kaarin J. ; Maeder, Anthony J. ; McNeil, John ; Jorm, Louisa ; Lautenschlager, Nicola T. ; Sachdev, Perminder S. ; Ginige, Jeewani A. ; Hobbs, Megan J. ; Boulamatsis, Christos ; Chau, Tiffany ; Cobiac, Lynne ; Cox, Kay L. ; Daniel, Kenneth ; Flood, Victoria M. ; Guerrero, Yareni ; Gunn, Jane ; Jain, Nidhi ; Kochan, Nicole A. ; Lampit, Amit ; Mavros, Yorgi ; Meiklejohn, Jacinda ; Noble, Yian ; O'Leary, Fiona ; Radd-Vagenas, Sue ; Walton, Courtney C. ; Brodaty, Henry. / Maintain Your Brain : Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds. In: Journal of Alzheimer's Disease. 2019 ; Vol. 70, No. s1. pp. S221-S237.
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title = "Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds",
abstract = "Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.",
keywords = "Alzheimer's disease, clinical trial, cognitive decline, cognitive training, dementia, depression, non-pharmacological, nutrition, physical activity, randomized controlled trial",
author = "Megan Heffernan and Gavin Andrews and {Fiatarone Singh}, {Maria A.} and Michael Valenzuela and Anstey, {Kaarin J.} and Maeder, {Anthony J.} and John McNeil and Louisa Jorm and Lautenschlager, {Nicola T.} and Sachdev, {Perminder S.} and Ginige, {Jeewani A.} and Hobbs, {Megan J.} and Christos Boulamatsis and Tiffany Chau and Lynne Cobiac and Cox, {Kay L.} and Kenneth Daniel and Flood, {Victoria M.} and Yareni Guerrero and Jane Gunn and Nidhi Jain and Kochan, {Nicole A.} and Amit Lampit and Yorgi Mavros and Jacinda Meiklejohn and Yian Noble and Fiona O'Leary and Sue Radd-Vagenas and Walton, {Courtney C.} and Henry Brodaty",
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Heffernan, M, Andrews, G, Fiatarone Singh, MA, Valenzuela, M, Anstey, KJ, Maeder, AJ, McNeil, J, Jorm, L, Lautenschlager, NT, Sachdev, PS, Ginige, JA, Hobbs, MJ, Boulamatsis, C, Chau, T, Cobiac, L, Cox, KL, Daniel, K, Flood, VM, Guerrero, Y, Gunn, J, Jain, N, Kochan, NA, Lampit, A, Mavros, Y, Meiklejohn, J, Noble, Y, O'Leary, F, Radd-Vagenas, S, Walton, CC & Brodaty, H 2019, 'Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds' Journal of Alzheimer's Disease, vol. 70, no. s1, pp. S221-S237. https://doi.org/10.3233/JAD-180572

Maintain Your Brain : Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds. / Heffernan, Megan; Andrews, Gavin; Fiatarone Singh, Maria A.; Valenzuela, Michael; Anstey, Kaarin J.; Maeder, Anthony J.; McNeil, John; Jorm, Louisa; Lautenschlager, Nicola T.; Sachdev, Perminder S.; Ginige, Jeewani A.; Hobbs, Megan J.; Boulamatsis, Christos; Chau, Tiffany; Cobiac, Lynne; Cox, Kay L.; Daniel, Kenneth; Flood, Victoria M.; Guerrero, Yareni; Gunn, Jane; Jain, Nidhi; Kochan, Nicole A.; Lampit, Amit; Mavros, Yorgi; Meiklejohn, Jacinda; Noble, Yian; O'Leary, Fiona; Radd-Vagenas, Sue; Walton, Courtney C.; Brodaty, Henry.

In: Journal of Alzheimer's Disease, Vol. 70, No. s1, 01.01.2019, p. S221-S237.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Maintain Your Brain

T2 - Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline among Community Dwelling 55 to 77 Year Olds

AU - Heffernan, Megan

AU - Andrews, Gavin

AU - Fiatarone Singh, Maria A.

AU - Valenzuela, Michael

AU - Anstey, Kaarin J.

AU - Maeder, Anthony J.

AU - McNeil, John

AU - Jorm, Louisa

AU - Lautenschlager, Nicola T.

AU - Sachdev, Perminder S.

AU - Ginige, Jeewani A.

AU - Hobbs, Megan J.

AU - Boulamatsis, Christos

AU - Chau, Tiffany

AU - Cobiac, Lynne

AU - Cox, Kay L.

AU - Daniel, Kenneth

AU - Flood, Victoria M.

AU - Guerrero, Yareni

AU - Gunn, Jane

AU - Jain, Nidhi

AU - Kochan, Nicole A.

AU - Lampit, Amit

AU - Mavros, Yorgi

AU - Meiklejohn, Jacinda

AU - Noble, Yian

AU - O'Leary, Fiona

AU - Radd-Vagenas, Sue

AU - Walton, Courtney C.

AU - Brodaty, Henry

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort. Methods: MYB aims to recruit 8,500 non-demented community dwelling 55 to 77 year olds from the Sax Institute's 45 and Up Study in New South Wales, Australia. Participants will be screened for risk factors related to four modules that comprise the MYB intervention: physical activity, nutrition, mental health, and cognitive training. Targeting risk factors will enable interventions to be personalized so that participants receive the most appropriate modules. MYB will run for three years and up to four modules will be delivered sequentially each quarter during year one. Upon completing a module, participants will continue to receive less frequent booster activities for their eligible modules (except for the mental health module) until the end of the trial. Discussion: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. If successful, MYB will provide a model for not just effective intervention among older adults, but an intervention that is scalable for broad use.

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KW - Alzheimer's disease

KW - clinical trial

KW - cognitive decline

KW - cognitive training

KW - dementia

KW - depression

KW - non-pharmacological

KW - nutrition

KW - physical activity

KW - randomized controlled trial

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U2 - 10.3233/JAD-180572

DO - 10.3233/JAD-180572

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SP - S221-S237

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

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