Macrophages and t cells in atherosclerosis: A translational perspective

Benjamin Bartlett, Herbert P. Ludewick, Ashish Misra, Silvia Lee, Girish Dwivedi

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Atherosclerosis is now considered a chronic maladaptive in-flammatory disease. The hallmark feature in both human and murine disease is atherosclerotic plaques. Macrophages and various T-cell lineages play a crucial role in atherosclerotic plaque establishment and disease progression. Humans and mice share many of the same processes that occur within atherogenesis. The various similarities enable considerable insight into disease mechanisms and those which contribute to cardiovascular complications. The apolipoprotein E-null and low-density lipoprotein receptor-null mice have served as the foundation for further immunological pathway manipulation to identify pro-and antiatherogenic pathways in attempt to reveal more novel therapeutic targets. In this review, we provide a translational perspective and discuss the roles of macrophages and various T-cell lineages in contrasting proatherosclerotic and atheroprotective settings.

Original languageEnglish
Pages (from-to)H375-H386
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume317
Issue number2
DOIs
Publication statusPublished - 1 Aug 2019

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