Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)

Kathryn J. Moore, Simon Koplev, Edward A. Fisher, Ira Tabas, Johan L.M. Björkegren, Amanda C. Doran, Jason C. Kovacic

Research output: Contribution to journalReview articlepeer-review

133 Citations (Scopus)

Abstract

Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall. These modified lipoproteins activate resident macrophages and the recruitment of monocyte-derived cells, which differentiate into mononuclear phagocytes that ingest the deposited lipoproteins to become “foam cells”: a hallmark of this disease. In this Part 2 of a 4-part review series covering the macrophage in cardiovascular disease, we critically review the contributions and relevant pathobiology of monocytes, macrophages, and foam cells as relevant to atherosclerosis. We also review evidence that via various pathways, a failure of the resolution of inflammation is an additional key aspect of this disease process. Finally, we consider the likely role played by genomics and biological networks in controlling the macrophage phenotype in atherosclerosis. Collectively, these data provide substantial insights on the atherosclerotic process, while concurrently offering numerous molecular and genomic candidates that appear to hold great promise for selective targeting as clinical therapies.
Original languageEnglish
Pages (from-to)2181-2197
Number of pages17
JournalJournal of the American College of Cardiology
Volume72
Issue number18
DOIs
Publication statusPublished - 30 Oct 2018
Externally publishedYes

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