Lupin allergy: Uncovering structural features and epitopes of β-conglutin proteins in Lupinus Angustifolius L. with a focus on cross-allergenic reactivity to peanut and other legumes

Jose Jimenez-Lopez, E. Lima-Cabello, S. Melser, R.C. Foley, Karam Singh, D. Alché Juan

Research output: Chapter in Book/Conference paperConference paper

8 Citations (Scopus)

Abstract

© Springer International Publishing Switzerland 2015. The use of sweet lupins as a new food is resulting in an increasing number of cases of allergy reactions, particularly in atopic patients with other pre-existing legume allergies. We performed an extensive in silico analysis of seed β-conglutins, a new family of major allergen proteins in lupin, and a comparison to other relevant food allergens such as Ara h 1. We analyzed surface residues involved in conformational epitopes, lineal B- and T-cell epitopes variability, and changes in 2-D structural elements and 3D motives, with the aim to investigate IgE-mediated cross-reactivity among lupin, peanut, and other different legumes. Our results revealed that considerable structural differences exist, particularly affecting 2-D elements (loops and coils), and numerous micro-heterogeneities are present in fundamental residues directly involved in epitopes variability. Variability of residues involved in IgE-binding epitopes might be a major contributor to the observed differences in cross-reactivity among legumes.
Original languageEnglish
Title of host publicationBioinformatics and Biomedical Engineering
Subtitle of host publicationThird International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015, Proceedings, Part I
EditorsFrancisco Ortuño, Ignacio Rojas
PublisherSpringer
Pages96-107
Volume1
ISBN (Electronic)9783319164830
ISBN (Print)9783319164823
DOIs
Publication statusPublished - 2015
Event3rd International Work-Conference on Bioinformatics and Biomedical Engineering - Granada, Spain
Duration: 15 Apr 201517 Apr 2015
Conference number: 3

Publication series

NameLecture Notes in Computer Science
PublisherSpringer
Volume9043
ISSN (Print)0302-9743
NameLecture Notes in Bioinformatics
PublisherSpringer
Volume9043

Conference

Conference3rd International Work-Conference on Bioinformatics and Biomedical Engineering
Abbreviated titleIWBBIO 2015
CountrySpain
CityGranada
Period15/04/1517/04/15

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