Lung ultrasound accurately detects pneumothorax in a preterm newborn lamb model

D.A. Blank, S.B. Hooper, C. Binder-Heschl, M. Kluckow, Andrew Gill, D.A. Larosa, I.M. Inocencio, A. Moxham, K. Rodgers, V.A. Zahra, P.G. Davis, G.R. Polglase

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    Abstract

    © 2016 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)Aim: Pneumothorax is a common emergency affecting extremely preterm. In adult studies, lung ultrasound has performed better than chest x-ray in the diagnosis of pneumothorax. The purpose of this study was to determine the efficacy of lung ultrasound (LUS) examination to detect pneumothorax using a preterm animal model. Methods: This was a prospective, observational study using newborn Border–Leicester lambs at gestational age = 126 days (equivalent to gestational age = 26 weeks in humans) receiving mechanical ventilation from birth to 2 h of life. At the conclusion of the experiment, LUS was performed, the lambs were then euthanised and a post-mortem exam was immediately performed. We used previously published ultrasound techniques to identify pneumothorax. Test characteristics of LUS to detect pneumothorax were calculated, using the post-mortem exam as the ‘gold standard’ test. Results: Nine lambs (18 lungs) were examined. Four lambs had a unilateral pneumothorax, all of which were identified by LUS with no false positives. Conclusions: This was the first study to use post-mortem findings to test the efficacy of LUS to detect pneumothorax in a newborn animal model. Lung ultrasound accurately detected pneumothorax, verified by post-mortem exam, in premature, newborn lambs.
    Original languageEnglish
    Pages (from-to)643-648
    JournalJournal of Paediatrics and Child Health
    Volume52
    Issue number6
    Early online date18 Apr 2016
    DOIs
    Publication statusPublished - Jun 2016

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    Blank, D. A., Hooper, S. B., Binder-Heschl, C., Kluckow, M., Gill, A., Larosa, D. A., ... Polglase, G. R. (2016). Lung ultrasound accurately detects pneumothorax in a preterm newborn lamb model. Journal of Paediatrics and Child Health, 52(6), 643-648. https://doi.org/10.1111/jpc.13154