Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

D. Taeger; B. Pesch; B. Kendzia; T. Behrens; K.H. Jöckel; D. Dahmann; J. Siemiatycki; H. Kromhout; R. Vermeulen; Susan Peters; A. Olsson; I. Brüske; H.E. Wichmann; I. Stücker; F. Guida; A. Tardón; F. Merletti; D. Mirabelli; L. Richiardi; H. Pohlabeln; W. Ahrens; M.T. Landi; N. Caporaso; A.C. Pesatori; A. Mukeriya; N. Szeszenia-Dabrowska; J. Lissowska; P. Gustavsson; J. Field; M.W. Marcus; E. Fabianova; A.T. Mannetje; N. Pearce; P. Rudnai; V. Bencko; V. Janout; R.S. Dumitru; L. Foretova; F. Forastiere; J. Mclaughlin; P. Demers; B. Bueno-De-Mesquita; J. Schüz; K. Straif; T. Brüning

doi:10.5271/sjweh.3513

Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

D. Taeger, B. Pesch, B. Kendzia, T. Behrens, K.H. Jöckel, D. Dahmann, J. Siemiatycki, H. Kromhout, R. Vermeulen, Susan Peters, A. Olsson, I. Brüske, H.E. Wichmann, I. Stücker, F. Guida, A. Tardón, F. Merletti, D. Mirabelli, L. Richiardi, H. PohlabelnW. Ahrens, M.T. Landi, N. Caporaso, A.C. Pesatori, A. Mukeriya, N. Szeszenia-Dabrowska, J. Lissowska, P. Gustavsson, J. Field, M.W. Marcus, E. Fabianova, A.T. Mannetje, N. Pearce, P. Rudnai, V. Bencko, V. Janout, R.S. Dumitru, L. Foretova, F. Forastiere, J. Mclaughlin, P. Demers, B. Bueno-De-Mesquita, J. Schüz, K. Straif, T. Brüning

School of Population and Global Health

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30 Citations (Scopus)

Abstract

© Scandinavian Journal of Work, Environment & Health. Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

Original language	English
Pages (from-to)	467-477
Journal	Scandinavian Journal of Work, Environment & Health
Volume	41
Issue number	5
DOIs	https://doi.org/10.5271/sjweh.3513
Publication status	Published - 2015

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10.5271/sjweh.3513

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Taeger, D., Pesch, B., Kendzia, B., Behrens, T., Jöckel, K. H., Dahmann, D., Siemiatycki, J., Kromhout, H., Vermeulen, R., Peters, S., Olsson, A., Brüske, I., Wichmann, H. E., Stücker, I., Guida, F., Tardón, A., Merletti, F., Mirabelli, D., Richiardi, L., ... Brüning, T. (2015). Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies. Scandinavian Journal of Work, Environment & Health, 41(5), 467-477. https://doi.org/10.5271/sjweh.3513

@article{abdbd73389b946138b0b2a7b73c05876,

title = "Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies",

abstract = "{\textcopyright} Scandinavian Journal of Work, Environment & Health. Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.",

author = "D. Taeger and B. Pesch and B. Kendzia and T. Behrens and K.H. J{\"o}ckel and D. Dahmann and J. Siemiatycki and H. Kromhout and R. Vermeulen and Susan Peters and A. Olsson and I. Br{\"u}ske and H.E. Wichmann and I. St{\"u}cker and F. Guida and A. Tard{\'o}n and F. Merletti and D. Mirabelli and L. Richiardi and H. Pohlabeln and W. Ahrens and M.T. Landi and N. Caporaso and A.C. Pesatori and A. Mukeriya and N. Szeszenia-Dabrowska and J. Lissowska and P. Gustavsson and J. Field and M.W. Marcus and E. Fabianova and A.T. Mannetje and N. Pearce and P. Rudnai and V. Bencko and V. Janout and R.S. Dumitru and L. Foretova and F. Forastiere and J. Mclaughlin and P. Demers and B. Bueno-De-Mesquita and J. Sch{\"u}z and K. Straif and T. Br{\"u}ning",

year = "2015",

doi = "10.5271/sjweh.3513",

language = "English",

volume = "41",

pages = "467--477",

journal = "Scandinavian Journal of Work, Environment & Health",

issn = "0355-3140",

publisher = "Finnish Institute of Occupational Health",

number = "5",

}

Taeger, D, Pesch, B, Kendzia, B, Behrens, T, Jöckel, KH, Dahmann, D, Siemiatycki, J, Kromhout, H, Vermeulen, R, Peters, S, Olsson, A, Brüske, I, Wichmann, HE, Stücker, I, Guida, F, Tardón, A, Merletti, F, Mirabelli, D, Richiardi, L, Pohlabeln, H, Ahrens, W, Landi, MT, Caporaso, N, Pesatori, AC, Mukeriya, A, Szeszenia-Dabrowska, N, Lissowska, J, Gustavsson, P, Field, J, Marcus, MW, Fabianova, E, Mannetje, AT, Pearce, N, Rudnai, P, Bencko, V, Janout, V, Dumitru, RS, Foretova, L, Forastiere, F, Mclaughlin, J, Demers, P, Bueno-De-Mesquita, B, Schüz, J, Straif, K & Brüning, T 2015, 'Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies', Scandinavian Journal of Work, Environment & Health, vol. 41, no. 5, pp. 467-477. https://doi.org/10.5271/sjweh.3513

TY - JOUR

T1 - Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

AU - Taeger, D.

AU - Pesch, B.

AU - Kendzia, B.

AU - Behrens, T.

AU - Jöckel, K.H.

AU - Dahmann, D.

AU - Siemiatycki, J.

AU - Kromhout, H.

AU - Vermeulen, R.

AU - Peters, Susan

AU - Olsson, A.

AU - Brüske, I.

AU - Wichmann, H.E.

AU - Stücker, I.

AU - Guida, F.

AU - Tardón, A.

AU - Merletti, F.

AU - Mirabelli, D.

AU - Richiardi, L.

AU - Pohlabeln, H.

AU - Ahrens, W.

AU - Landi, M.T.

AU - Caporaso, N.

AU - Pesatori, A.C.

AU - Mukeriya, A.

AU - Szeszenia-Dabrowska, N.

AU - Lissowska, J.

AU - Gustavsson, P.

AU - Field, J.

AU - Marcus, M.W.

AU - Fabianova, E.

AU - Mannetje, A.T.

AU - Pearce, N.

AU - Rudnai, P.

AU - Bencko, V.

AU - Janout, V.

AU - Dumitru, R.S.

AU - Foretova, L.

AU - Forastiere, F.

AU - Mclaughlin, J.

AU - Demers, P.

AU - Bueno-De-Mesquita, B.

AU - Schüz, J.

AU - Straif, K.

AU - Brüning, T.

PY - 2015

Y1 - 2015

N2 - © Scandinavian Journal of Work, Environment & Health. Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

AB - © Scandinavian Journal of Work, Environment & Health. Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

U2 - 10.5271/sjweh.3513

DO - 10.5271/sjweh.3513

M3 - Article

C2 - 26153779

SN - 0355-3140

VL - 41

SP - 467

EP - 477

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

IS - 5

ER -

Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

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