Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Objective Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease. This relationship may be modulated to some extent by age-related changes in sex hormone status. We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity.Design Cross-sectional analysis of 2470 community-dwelling non-diabetic men aged ≥70 years.Methods Age, body mass index (BMI) and waist circumference were measured. Early morning sera were assayed for total testosterone, SHBG, LH and insulin levels. Free testosterone was calculated using mass action equations, and insulin resistance was assessed using a homeostatic model (HOMA2-IR).Results Total testosterone, free testosterone and SHBG declined progressively across increasing quintiles of HOMA2-IR (all P
Original languageEnglish
Pages (from-to)591-98
JournalEuropean Journal of Endocrinology
Volume161
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study'. Together they form a unique fingerprint.

Cite this