Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease

Laura H Eggermont; Brandon E Gavett; Karin M Volkers; Christiaan G Blankevoort; Erik J Scherder; Angela L Jefferson; Eric Steinberg; Anil Nair; Robert C Green; Robert A Stern

doi:10.1016/j.apmr.2009.11.020

Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease

Laura H Eggermont, Brandon E Gavett, Karin M Volkers, Christiaan G Blankevoort, Erik J Scherder, Angela L Jefferson, Eric Steinberg, Anil Nair, Robert C Green, Robert A Stern

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

OBJECTIVE: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).

DESIGN: Descriptive study.

SETTING: University Alzheimer's disease clinical and research program.

PARTICIPANTS: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.

INTERVENTIONS: Not applicable.

MAIN OUTCOME MEASURES: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.

RESULTS: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.

CONCLUSIONS: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

Original language	English
Pages (from-to)	584-8
Number of pages	5
Journal	Archives of Physical Medicine and Rehabilitation
Volume	91
Issue number	4
DOIs	https://doi.org/10.1016/j.apmr.2009.11.020
Publication status	Published - Apr 2010
Externally published	Yes

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Eggermont, L. H., Gavett, B. E., Volkers, K. M., Blankevoort, C. G., Scherder, E. J., Jefferson, A. L., Steinberg, E., Nair, A., Green, R. C., & Stern, R. A. (2010). Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Archives of Physical Medicine and Rehabilitation, 91(4), 584-8. https://doi.org/10.1016/j.apmr.2009.11.020

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abstract = "OBJECTIVE: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).DESIGN: Descriptive study.SETTING: University Alzheimer's disease clinical and research program.PARTICIPANTS: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.RESULTS: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.CONCLUSIONS: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.",

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year = "2010",

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doi = "10.1016/j.apmr.2009.11.020",

language = "English",

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AU - Eggermont, Laura H

AU - Gavett, Brandon E

AU - Volkers, Karin M

AU - Blankevoort, Christiaan G

AU - Scherder, Erik J

AU - Jefferson, Angela L

AU - Steinberg, Eric

AU - Nair, Anil

AU - Green, Robert C

AU - Stern, Robert A

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N2 - OBJECTIVE: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).DESIGN: Descriptive study.SETTING: University Alzheimer's disease clinical and research program.PARTICIPANTS: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.RESULTS: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.CONCLUSIONS: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

AB - OBJECTIVE: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).DESIGN: Descriptive study.SETTING: University Alzheimer's disease clinical and research program.PARTICIPANTS: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.INTERVENTIONS: Not applicable.MAIN OUTCOME MEASURES: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.RESULTS: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.CONCLUSIONS: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

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KW - Humans

KW - Lower Extremity/physiology

KW - Male

KW - Middle Aged

KW - Physical Therapy Modalities

KW - Severity of Illness Index

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JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

SN - 0003-9993

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ER -

Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease

Abstract

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