Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with depressive symptoms. However, the link between 25(OH)-vitamin D status in pregnancy and altered risk of postnatal depressive symptoms has not been examined. We hypothesise that low levels of 25(OH)-vitamin D in maternal serum during pregnancy will be associated with a higher incidence of postpartum depressive symptoms. We prospectively collected sera at 18 weeks gestation from 796 pregnant women in Perth (1989-1992) who were enrolled in the Western Australian Pregnancy Cohort (Raine) Study and measured levels of 25(OH)-vitamin D. Women reported postnatal depressive symptoms at 3 days post-delivery. Women in the lowest quartile for 25(OH)-vitamin D status were more likely to report a higher level of postnatal depression symptoms than women who were in the highest quartile for vitamin D, even after accounting for a range of confounding variables including season of birth, body mass index and sociodemographic factors. Low vitamin D during pregnancy is a risk factor for the development of postpartum depression symptoms. © 2014 Springer-Verlag.
Robinson, M., Whitehouse, A., Newnham, J., Gorman, S., Jacoby, P., Holt, B. J., Serralha, M., Tearne, J., Holt, P., Hart, P., & Kusel, M. (2014). Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms. Archives of Women's Mental Health, 17(3), 213-219. https://doi.org/10.1007/s00737-014-0422-y