LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

W. Xu; Heng Chooi; J.W. Choi; S. Li; J.C. Vederas; N.A. Da Silva; Y. Tang

doi:10.1002/anie.201302406

LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

W. Xu, Heng Chooi, J.W. Choi, S. Li, J.C. Vederas, N.A. Da Silva, Y. Tang

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	6472-6475
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	25
DOIs	https://doi.org/10.1002/anie.201302406
Publication status	Published - 2013

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title = "LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis",

abstract = "No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis. Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

author = "W. Xu and Heng Chooi and J.W. Choi and S. Li and J.C. Vederas and {Da Silva}, N.A. and Y. Tang",

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AU - Xu, W.

AU - Chooi, Heng

AU - Choi, J.W.

AU - Li, S.

AU - Vederas, J.C.

AU - Da Silva, N.A.

AU - Tang, Y.

PY - 2013

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AB - No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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DO - 10.1002/anie.201302406

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

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ER -

LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

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