LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

W. Xu, Heng Chooi, J.W. Choi, S. Li, J.C. Vederas, N.A. Da Silva, Y. Tang

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)6472-6475
JournalAngewandte Chemie - International Edition
Volume52
Issue number25
DOIs
Publication statusPublished - 2013

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Lovastatin
Catalysis
Hydrolysis
dihydromonacolin L

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title = "LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis",
abstract = "No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis. Copyright {\circledC} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
author = "W. Xu and Heng Chooi and J.W. Choi and S. Li and J.C. Vederas and {Da Silva}, N.A. and Y. Tang",
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pages = "6472--6475",
journal = "Angewandte Chemie - International Edition",
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LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. / Xu, W.; Chooi, Heng; Choi, J.W.; Li, S.; Vederas, J.C.; Da Silva, N.A.; Tang, Y.

In: Angewandte Chemie - International Edition, Vol. 52, No. 25, 2013, p. 6472-6475.

Research output: Contribution to journalArticle

TY - JOUR

T1 - LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

AU - Xu, W.

AU - Chooi, Heng

AU - Choi, J.W.

AU - Li, S.

AU - Vederas, J.C.

AU - Da Silva, N.A.

AU - Tang, Y.

PY - 2013

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U2 - 10.1002/anie.201302406

DO - 10.1002/anie.201302406

M3 - Article

VL - 52

SP - 6472

EP - 6475

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

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