TY - JOUR
T1 - Loss of heterozygosity on chromosome 2q
T2 - Possibly a poor prognostic factor in head and neck cancer
AU - Ransom, David T.
AU - Barnett, Timothy C.
AU - Bot, Joan
AU - De Boer, Bastiaan
AU - Metcalf, Cecily
AU - Davidson, J. Andrew
AU - Turbett, Gavin R.
PY - 1998/8/1
Y1 - 1998/8/1
N2 - Background. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. The aim of this study was to see if LOH on chromosomes 2q, 3p, 5q, 9p, and 17p correlated with survival in early squamous cell carcinoma of the head and neck (SCCHN). Methods. A case control study was performed. Ten patients with stage I or II tumors who ultimately died of their disease were identified and matched with suitable controls. None of the controls had s local recurrence and at time of last follow-up were alive with no evidence of disease or had died of an unrelated illness. The deoxyribonucleic acid (DNA) was extracted from paraffin blocks, and LOH studies were performed using microsatellite markers. Results. The respective incidence of allelic loss for the index and control patients was as follows: chromosome 2q, 75% and 20% (p = .03); chromosome 3p, 71% and 57%, respectively (not significant); chromosome arm 5q, 30% and 25% (not significant); chromosome arm 9p, 71% and 73% (not significant); and chromosome arm 17p, 75% and 46% (not significant). Therefore, loss on chromosome 2q strongly correlated with poor survival (odds ratio = 10.4). Conclusion. Loss of heterozygosity on chromosome 2q may correlate with a poor prognosis in early-stage SCCHN.
AB - Background. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. The aim of this study was to see if LOH on chromosomes 2q, 3p, 5q, 9p, and 17p correlated with survival in early squamous cell carcinoma of the head and neck (SCCHN). Methods. A case control study was performed. Ten patients with stage I or II tumors who ultimately died of their disease were identified and matched with suitable controls. None of the controls had s local recurrence and at time of last follow-up were alive with no evidence of disease or had died of an unrelated illness. The deoxyribonucleic acid (DNA) was extracted from paraffin blocks, and LOH studies were performed using microsatellite markers. Results. The respective incidence of allelic loss for the index and control patients was as follows: chromosome 2q, 75% and 20% (p = .03); chromosome 3p, 71% and 57%, respectively (not significant); chromosome arm 5q, 30% and 25% (not significant); chromosome arm 9p, 71% and 73% (not significant); and chromosome arm 17p, 75% and 46% (not significant). Therefore, loss on chromosome 2q strongly correlated with poor survival (odds ratio = 10.4). Conclusion. Loss of heterozygosity on chromosome 2q may correlate with a poor prognosis in early-stage SCCHN.
KW - Chromosome 2
KW - Head and neck neoplasms
KW - Loss of heterozygosity
UR - http://www.scopus.com/inward/record.url?scp=0031806636&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0347(199808)20:5<404::AID-HED8>3.0.CO;2-1
DO - 10.1002/(SICI)1097-0347(199808)20:5<404::AID-HED8>3.0.CO;2-1
M3 - Article
C2 - 9663668
AN - SCOPUS:0031806636
SN - 1043-3074
VL - 20
SP - 404
EP - 410
JO - Head and Neck
JF - Head and Neck
IS - 5
ER -