Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage

Stuart A. Newman; J. Birnbaum; George C.T. Yeoh

doi:10.1038/259417a0

Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage

Stuart A. Newman, J. Birnbaum, George C.T. Yeoh

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression^1-6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species⁴, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription^5,6.

Original language	English
Pages (from-to)	417-418
Number of pages	2
Journal	Nature
Volume	259
Issue number	5542
DOIs	https://doi.org/10.1038/259417a0
Publication status	Published - 1 Dec 1976
Externally published	Yes

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abstract = "SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1-6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.",

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AU - Birnbaum, J.

AU - Yeoh, George C.T.

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N2 - SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1-6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.

AB - SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1-6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.

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Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage

Abstract

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