Loss of a non-histone chromatin protein parallels in vitro differentiation of cartilage

Stuart A. Newman, J. Birnbaum, George C.T. Yeoh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

SEVERAL lines of evidence have implicated the proteins associated with the nuclear DNA of eukaryotic cells in the control of differential gene expression1-6. In contrast to the histones of eukaryotic chromatin which are relatively conserved in both primary structure and distribution across cell types within an organism, and from species to species4, the non-histone chromosomal proteins are very variable in size and distribution. This lends weight to the presumption that they are the specific regulators of transcription5,6.

Original languageEnglish
Pages (from-to)417-418
Number of pages2
JournalNature
Volume259
Issue number5542
DOIs
Publication statusPublished - 1 Dec 1976
Externally publishedYes

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