TY - JOUR
T1 - Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease
AU - Xia, Ying
AU - Maruff, Paul
AU - Doré, Vincent
AU - Bourgeat, Pierrick
AU - Laws, Simon M.
AU - Fowler, Christopher
AU - Rainey-Smith, Stephanie R.
AU - Martins, Ralph N.
AU - Villemagne, Victor L.
AU - Rowe, Christopher C.
AU - Masters, Colin L.
AU - Coulson, Elizabeth J.
AU - Fripp, Jurgen
N1 - Funding Information:
We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. We kindly thank all Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group members (http://aibl.csiro.au/about/aibl-research-team/). The AIBL study (http://www.AIBL.csiro.au) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. Partial financial support provided by the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support program, the McCusker Alzheimer's Research Foundation, the National Health and Medical Research Council, as well as the Cooperative Research Centre for Mental Health. Numerous commercial interactions have supported data collection and analysis. In-kind support has also been provided by Sir Charles Gairdner Hospital, the University of Melbourne, and St Vincent's Hospital.
Funding Information:
We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. We kindly thank all Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group members ( http://aibl.csiro.au/about/aibl-research-team/ ). The AIBL study ( http://www.AIBL.csiro.au ) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. Partial financial support provided by the Alzheimer’s Association (US), the Alzheimer’s Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government’s Operational Infrastructure Support program, the McCusker Alzheimer’s Research Foundation, the National Health and Medical Research Council, as well as the Cooperative Research Centre for Mental Health. Numerous commercial interactions have supported data collection and analysis. In-kind support has also been provided by Sir Charles Gairdner Hospital, the University of Melbourne, and St Vincent’s Hospital.
Funding Information:
The Australian Imaging, Biomarkers and Lifestyle study ( http://www.AIBL.csiro.au ) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. Partial financial support provided by the Alzheimer’s Association (US), the Alzheimer’s Drug Discovery Foundation, an anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government’s Operational Infrastructure Support program, the McCusker Alzheimer’s Research Foundation, the National Health and Medical Research Council, as well as the Cooperative Research Centre for Mental Health. Numerous commercial interactions have supported data collection and analysis. In-kind support has also been provided by Sir Charles Gairdner Hospital, the University of Melbourne, and St Vincent’s Hospital.
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/12
Y1 - 2023/12
N2 - Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.
AB - Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.
KW - Alzheimer's disease
KW - Amyloid-β
KW - Basal forebrain
KW - Longitudinal
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85173166887&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2023.09.002
DO - 10.1016/j.neurobiolaging.2023.09.002
M3 - Article
C2 - 37801885
AN - SCOPUS:85173166887
SN - 0197-4580
VL - 132
SP - 120
EP - 130
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -