Long-term benzodiazepine use in patients with major depressive disorder in China

Y. Li, Y. Xiang, Y. Su, L. Shu, X. Yu, A.M. Kilbourne, Gabor Ungvári, H. Chiu, G. Wang, P. Bai, X. Liu, L. Sun, J. Shi, X. Chen, Q. Mei, K. Li, T. Si

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    Abstract

    Purpose: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD. Design and Methods: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form. Findings: A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors). Practice Implications: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use. © 2013 Wiley Periodicals, Inc.
    Original languageEnglish
    Pages (from-to)149-154
    JournalPerspectives in Psychiatric Care
    Volume50
    Issue number3
    DOIs
    Publication statusPublished - 2014

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    Major Depressive Disorder
    Benzodiazepines
    China
    Demography
    Antidepressive Agents
    Antipsychotic Agents
    Monoamine Oxidase Inhibitors
    Prescription Drugs
    Tricyclic Antidepressive Agents
    Psychotropic Drugs
    Mental Health
    Multivariate Analysis

    Cite this

    Li, Y., Xiang, Y., Su, Y., Shu, L., Yu, X., Kilbourne, A. M., ... Si, T. (2014). Long-term benzodiazepine use in patients with major depressive disorder in China. Perspectives in Psychiatric Care, 50(3), 149-154. https://doi.org/10.1111/ppc.12035
    Li, Y. ; Xiang, Y. ; Su, Y. ; Shu, L. ; Yu, X. ; Kilbourne, A.M. ; Ungvári, Gabor ; Chiu, H. ; Wang, G. ; Bai, P. ; Liu, X. ; Sun, L. ; Shi, J. ; Chen, X. ; Mei, Q. ; Li, K. ; Si, T. / Long-term benzodiazepine use in patients with major depressive disorder in China. In: Perspectives in Psychiatric Care. 2014 ; Vol. 50, No. 3. pp. 149-154.
    @article{b6dae9c1f193438f8045e040aad0f629,
    title = "Long-term benzodiazepine use in patients with major depressive disorder in China",
    abstract = "Purpose: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD. Design and Methods: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form. Findings: A large portion of patients (36.2{\%}) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors). Practice Implications: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use. {\circledC} 2013 Wiley Periodicals, Inc.",
    author = "Y. Li and Y. Xiang and Y. Su and L. Shu and X. Yu and A.M. Kilbourne and Gabor Ungv{\'a}ri and H. Chiu and G. Wang and P. Bai and X. Liu and L. Sun and J. Shi and X. Chen and Q. Mei and K. Li and T. Si",
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    Li, Y, Xiang, Y, Su, Y, Shu, L, Yu, X, Kilbourne, AM, Ungvári, G, Chiu, H, Wang, G, Bai, P, Liu, X, Sun, L, Shi, J, Chen, X, Mei, Q, Li, K & Si, T 2014, 'Long-term benzodiazepine use in patients with major depressive disorder in China' Perspectives in Psychiatric Care, vol. 50, no. 3, pp. 149-154. https://doi.org/10.1111/ppc.12035

    Long-term benzodiazepine use in patients with major depressive disorder in China. / Li, Y.; Xiang, Y.; Su, Y.; Shu, L.; Yu, X.; Kilbourne, A.M.; Ungvári, Gabor; Chiu, H.; Wang, G.; Bai, P.; Liu, X.; Sun, L.; Shi, J.; Chen, X.; Mei, Q.; Li, K.; Si, T.

    In: Perspectives in Psychiatric Care, Vol. 50, No. 3, 2014, p. 149-154.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Long-term benzodiazepine use in patients with major depressive disorder in China

    AU - Li, Y.

    AU - Xiang, Y.

    AU - Su, Y.

    AU - Shu, L.

    AU - Yu, X.

    AU - Kilbourne, A.M.

    AU - Ungvári, Gabor

    AU - Chiu, H.

    AU - Wang, G.

    AU - Bai, P.

    AU - Liu, X.

    AU - Sun, L.

    AU - Shi, J.

    AU - Chen, X.

    AU - Mei, Q.

    AU - Li, K.

    AU - Si, T.

    PY - 2014

    Y1 - 2014

    N2 - Purpose: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD. Design and Methods: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form. Findings: A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors). Practice Implications: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use. © 2013 Wiley Periodicals, Inc.

    AB - Purpose: There have been no data about long-term benzodiazepine (BZD) use and its correlates in patients with major depressive disorder (MDD) in China. This study aimed to examine the prevalence of long-term BZD use (more than three months) and its demographic and clinical correlates in Chinese patients with MDD. Design and Methods: A total of 1,192 patients with MDD were examined in 10 mental health centers in China. Patients' socio-demographic and clinical characteristics and prescriptions for psychotropic drugs were recorded using a standardized form. Findings: A large portion of patients (36.2%) received long-term BZD treatment. Univariate analyses revealed that long-term BZD users were older, poorer, and had more impaired occupational functioning than patients not taking BZDs. Long-term BZD users had fewer psychotic symptoms and took less antipsychotic drugs. In multivariate analyses, long-term BZD use was independently associated with older age and more severe impaired occupational functioning; long-term BZD users were less likely to receive antipsychotic medications and traditional antidepressants (tricyclic antidepressants, tetracyclic antidepressant, and monoamine oxidase inhibitors). Practice Implications: Long-term BZD use was common in patients with MDD in China. A host of demographic and clinical factors were independently associated with long-term BZD use. © 2013 Wiley Periodicals, Inc.

    U2 - 10.1111/ppc.12035

    DO - 10.1111/ppc.12035

    M3 - Article

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    EP - 154

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    JF - Perspectives in Psychiatric Care

    SN - 0031-5990

    IS - 3

    ER -