Long-term allograft and patient outcomes of kidney transplant recipients with and without incident cancer - a population cohort study

Wai H. Lim, Sunil V. Badve, Germaine Wong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The excess risk for cancer in kidney transplant recipients is substantial, but the allograft and patient survivals after cancer development are under-studied. This is a population-based cohort study of all primary live and deceased donor kidney transplant recipients in Australia and New Zealand between 1990-2012. The risks of overall graft loss and death with a functioning graft in kidney transplant recipients with and without incident cancer were determined using adjusted Cox regression analysis, with incident cancer considered as a time-varying covariate in the models. In those with incident cancer, types and cancer stage at diagnoses were reported. Of 12,545 transplant recipients followed for a median of 6.9 years (91,380 patient-years), 1184 (9.4%) developed incident cancers at a median of 5.8 years post-transplant. Digestive, kidney and urinary tract cancers were the most common cancer types, although digestive and respiratory tract cancers were more aggressive, with 40% reported as advanced cancers at time of cancer diagnosis. Cancer-related deaths accounted for approximately 80% of recipients with a prior cancer history. Compared with recipients with no prior cancer, the adjusted hazard ratios (HR) for overall graft loss and death with functioning graft were 4.34 (95% CI 3.90, 4.82; p

Original languageEnglish
Pages (from-to)77771-77782
Number of pages12
JournalOncotarget
Volume8
Issue number44
DOIs
Publication statusPublished - 29 Sep 2017

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