Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

T.C. Brodnicki; A.L. Fletcher; D.G. Pellicci; S.P. Berzins; P. Mcclive; F. Quirk; K.E. Webster; H.S. Scott; R.L. Boyd; D.I. Godfrey; Grant Morahan

doi:10.2337/diabetes.54.12.3453

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

T.C. Brodnicki, A.L. Fletcher, D.G. Pellicci, S.P. Berzins, P. Mcclive, F. Quirk, K.E. Webster, H.S. Scott, R.L. Boyd, D.I. Godfrey, Grant Morahan

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an ∼8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

Original language	English
Pages (from-to)	3453-3457
Journal	Diabetes
Volume	54
Issue number	12
DOIs	https://doi.org/10.2337/diabetes.54.12.3453
Publication status	Published - 2005

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title = "Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice",

abstract = "Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an ∼8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.",

author = "T.C. Brodnicki and A.L. Fletcher and D.G. Pellicci and S.P. Berzins and P. Mcclive and F. Quirk and K.E. Webster and H.S. Scott and R.L. Boyd and D.I. Godfrey and Grant Morahan",

year = "2005",

doi = "10.2337/diabetes.54.12.3453",

language = "English",

volume = "54",

pages = "3453--3457",

journal = "Diabetes",

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publisher = "American Diabetes Association",

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TY - JOUR

T1 - Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

AU - Brodnicki, T.C.

AU - Fletcher, A.L.

AU - Pellicci, D.G.

AU - Berzins, S.P.

AU - Mcclive, P.

AU - Quirk, F.

AU - Webster, K.E.

AU - Scott, H.S.

AU - Boyd, R.L.

AU - Godfrey, D.I.

AU - Morahan, Grant

PY - 2005

Y1 - 2005

N2 - Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an ∼8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

AB - Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an ∼8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.

U2 - 10.2337/diabetes.54.12.3453

DO - 10.2337/diabetes.54.12.3453

M3 - Article

SN - 0012-1797

VL - 54

SP - 3453

EP - 3457

JO - Diabetes

JF - Diabetes

IS - 12

ER -

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

Abstract

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