Localisation of the MRX3 gene for non-specific X linked mental retardation

A. Gedeon, B. Kerr, J. Mulley, G. Turner

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Abstract

A family is described with five affected males segregating a new gene for non-specific X linked mental retardation (MRX). Linkage analysis localised the gene at Xq28-qter. The maximum lod score was 2-89 with DXS52 (Stl4) at θ = 0.0. A recombinant was observed with DXS304 (U6.2) defining the proximal limit to the localisation. No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRX1 and MRX2. This delineates the third gene for non-specific X linked mental retardation, MRX3.

Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalJournal of Medical Genetics
Volume28
Issue number6
Publication statusPublished - 18 Jun 1991
Externally publishedYes

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