TY - JOUR
T1 - Local nitroglycerin to facilitate peripheral arterial cannulation in children
T2 - systematic review and meta-analysis
AU - Wagh, Deepika
AU - Pawale, Dinesh
AU - Tan, Jason Khay Ghim
AU - Rao, Shripada C.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background Neonates and children admitted to intensive care units require peripheral arterial cannulation to monitor their blood pressures and for blood sampling, but many times it is unsuccessful. Objective To conduct a systematic review and meta-analysis to evaluate the efficacy and safety of local nitroglycerin (NTG) to facilitate peripheral artery cannulation in neonates and children. Review methods PubMed, EMBASE, CINAHL, Emcare and Cochrane library were searched till August 2021. Grey literature was searched through Mednar. Data were extracted by two reviewers independently using a prespecified form and the risk of bias was assessed. Meta-analysis was conducted using a random-effects model. The I-2 statistic was used to quantify statistical heterogeneity. Certainty of evidence was assessed using the criteria of inconsistency, imprecision, indirectness, publication bias and size of effect as per the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines. Results Two randomised controlled trials (RCTs) were included in this meta-analysis (n=153). One was conducted in children 2-8 years of age and the other was in childrenTopical nitroglycerin may hep arterial cannulation.
AB - Background Neonates and children admitted to intensive care units require peripheral arterial cannulation to monitor their blood pressures and for blood sampling, but many times it is unsuccessful. Objective To conduct a systematic review and meta-analysis to evaluate the efficacy and safety of local nitroglycerin (NTG) to facilitate peripheral artery cannulation in neonates and children. Review methods PubMed, EMBASE, CINAHL, Emcare and Cochrane library were searched till August 2021. Grey literature was searched through Mednar. Data were extracted by two reviewers independently using a prespecified form and the risk of bias was assessed. Meta-analysis was conducted using a random-effects model. The I-2 statistic was used to quantify statistical heterogeneity. Certainty of evidence was assessed using the criteria of inconsistency, imprecision, indirectness, publication bias and size of effect as per the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines. Results Two randomised controlled trials (RCTs) were included in this meta-analysis (n=153). One was conducted in children 2-8 years of age and the other was in childrenTopical nitroglycerin may hep arterial cannulation.
KW - paediatrics
KW - intensive care units
KW - paediatric
KW - TOPICAL NITROGLYCERIN
KW - CATHETERIZATION
KW - TRIAL
KW - COMPLICATIONS
U2 - 10.1136/archdischild-2021-323757
DO - 10.1136/archdischild-2021-323757
M3 - Review article
C2 - 35595521
SN - 0003-9888
VL - 107
SP - 890
EP - 895
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
IS - 10
M1 - archdischild-2021-323757
ER -