Local nitroglycerin to facilitate peripheral arterial cannulation in children: systematic review and meta-analysis

Deepika Wagh, Dinesh Pawale, Jason Khay Ghim Tan, Shripada C. Rao

Research output: Contribution to journalReview articlepeer-review

Abstract

Background Neonates and children admitted to intensive care units require peripheral arterial cannulation to monitor their blood pressures and for blood sampling, but many times it is unsuccessful. Objective To conduct a systematic review and meta-analysis to evaluate the efficacy and safety of local nitroglycerin (NTG) to facilitate peripheral artery cannulation in neonates and children. Review methods PubMed, EMBASE, CINAHL, Emcare and Cochrane library were searched till August 2021. Grey literature was searched through Mednar. Data were extracted by two reviewers independently using a prespecified form and the risk of bias was assessed. Meta-analysis was conducted using a random-effects model. The I-2 statistic was used to quantify statistical heterogeneity. Certainty of evidence was assessed using the criteria of inconsistency, imprecision, indirectness, publication bias and size of effect as per the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines. Results Two randomised controlled trials (RCTs) were included in this meta-analysis (n=153). One was conducted in children 2-8 years of age and the other was in childrenTopical nitroglycerin may hep arterial cannulation.
Original languageEnglish
Article numberarchdischild-2021-323757
Number of pages6
JournalArchives of Disease in Childhood
DOIs
Publication statusE-pub ahead of print - 20 May 2022

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