TY - JOUR
T1 - Lipoprotein (a) and diabetes mellitus
T2 - causes and consequences
AU - Ward, Natalie C.
AU - Vickneswaran, Shayimeera
AU - Watts, Gerald F.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - PURPOSE OF REVIEW: This review provides an update on the role of lipoprotein (a) [Lp(a)] in diabetes, including its impact as a risk factor as well as its contribution to the development of cardiovascular disease. RECENT FINDINGS: Although a specific role for Lp(a) has not yet been conclusively established, it appears to have an inverse association with risk of diabetes. Several population-based studies have demonstrated associations between low levels of Lp(a) and increased risk of type 2 diabetes, but Mendelian randomization studies do not consistently support causality. Conversely, in patients with type 2 diabetes, elevated Lp(a) levels are associated with an increased risk of cardiovascular events. SUMMARY: Although Lp(a) contributes to the development of cardiovascular disease in patients with diabetes, few trials have investigated the benefits of reducing Lp(a) within this patient population. Furthermore, guidelines do not specifically address the risk associated with elevated Lp(a) levels. Despite this, Lp(a) should be measured in patients with diabetes and considered when evaluating their overall risk burden.
AB - PURPOSE OF REVIEW: This review provides an update on the role of lipoprotein (a) [Lp(a)] in diabetes, including its impact as a risk factor as well as its contribution to the development of cardiovascular disease. RECENT FINDINGS: Although a specific role for Lp(a) has not yet been conclusively established, it appears to have an inverse association with risk of diabetes. Several population-based studies have demonstrated associations between low levels of Lp(a) and increased risk of type 2 diabetes, but Mendelian randomization studies do not consistently support causality. Conversely, in patients with type 2 diabetes, elevated Lp(a) levels are associated with an increased risk of cardiovascular events. SUMMARY: Although Lp(a) contributes to the development of cardiovascular disease in patients with diabetes, few trials have investigated the benefits of reducing Lp(a) within this patient population. Furthermore, guidelines do not specifically address the risk associated with elevated Lp(a) levels. Despite this, Lp(a) should be measured in patients with diabetes and considered when evaluating their overall risk burden.
UR - http://www.scopus.com/inward/record.url?scp=85102217192&partnerID=8YFLogxK
U2 - 10.1097/MED.0000000000000597
DO - 10.1097/MED.0000000000000597
M3 - Article
C2 - 33229929
AN - SCOPUS:85102217192
SN - 1752-296X
VL - 28
SP - 181
EP - 187
JO - Current opinion in endocrinology, diabetes, and obesity
JF - Current opinion in endocrinology, diabetes, and obesity
IS - 2
ER -