Linkage to 10q22 for maximum intraocular pressure and 1p32 for maximum cup-to-disc ratio in an extended primary open-angle glaucoma pedigree

J.C. Charlesworth, T.D. Dyer, J.M. Stankovich, J. Blangero, David Mackey, J.E. Craig, C.M. Green, S.J. Foote, P.N. Baird, M.M. Sale

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Abstract

purpose. The purpose of this study was to identify genetic contributions to primary open-angle glaucoma (POAG) through investigations of two quantitative components of the POAG phenotype.methods. Genome-wide multipoint variance–components linkage analyses of maximum recorded intraocular pressure (IOP) and maximum vertical cup-to-disc ratio were conducted on data from a single, large Australian POAG pedigree that has been found to segregate the myocilin Q368X mutation in some individuals.results. Multipoint linkage analysis of maximum recorded IOP produced a peak LOD score of 3.3 (P = 0.00015) near marker D10S537 on 10q22, whereas the maximum cup-to-disc ratio produced a peak LOD score of 2.3 (P = 0.00056) near markers D1S197 to D1S220 on 1p32. Inclusion of the myocilin Q368X mutation as a covariate provided evidence of an interaction between this mutation and the IOP and cup-to-disc ratio loci.conclusions. Significant linkage has been identified for maximum IOP and suggestive linkage for vertical cup-to-disc ratio. Identification of genes contributing to the variance of these traits will enhance understanding of the pathophysiology of POAG as a whole.
Original languageEnglish
Pages (from-to)3723-3729
JournalInvestigative Ophthalmology and Visual Science
Volume46
Issue number10
DOIs
Publication statusPublished - 2005

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    Charlesworth, J. C., Dyer, T. D., Stankovich, J. M., Blangero, J., Mackey, D., Craig, J. E., Green, C. M., Foote, S. J., Baird, P. N., & Sale, M. M. (2005). Linkage to 10q22 for maximum intraocular pressure and 1p32 for maximum cup-to-disc ratio in an extended primary open-angle glaucoma pedigree. Investigative Ophthalmology and Visual Science, 46(10), 3723-3729. https://doi.org/10.1167/iovs.05-0312