TY - JOUR
T1 - Linkage analysis in bipolar pedigrees adds support for a susceptibility locus on 21q22
AU - Kaneva, R.P.
AU - Chorbov, V.M.
AU - Milanova, V.K.
AU - Kostov, C.S.
AU - Nickolov, K.I.
AU - Chakarova, C.F.
AU - Stoyanova, V.S.
AU - Nikolova-Hill, A.N.
AU - Krastev, S.K.
AU - Onchev, G.N.
AU - Kremensky, I.M.
AU - Kalaydjieva, Luba
AU - Jablensky, Assen
PY - 2004
Y1 - 2004
N2 - Several studies provide suggestive evidence of a susceptibility locus for bipolar disorder at chromosome 21q22-23. In an attempt to replicate these findings, we have analyzed linkage to 11 polymorphic markers from this region in 18 Bulgarian pedigrees with affective disorder. Two-point linkage analysis under assumption of homogeneity and a dominant model with reduced penetrance produced modest positive values for some of the markers tested under a 'narrow' phenotype definition, including bipolar I and II, and schizoaffective disorder. The maximum two-point score (lod = 1.76, theta = 0.00) was at marker D21S1919. Non-parametric linkage analysis under the same phenotype model, yielded positive NPLall values (P < 0.05) over the region between markers D21S211 and D21S416, with a peak at D21S1252 (NPL Zall = 2.32, P = 0.0003). The multipoint lod score (GENEHUNTER) reached a suggestive value for linkage (lod = 2.10) also at marker D21S1252. The results under a recessive model were completely negative. These data add to the evidence for the existence of a susceptibility locus for bipolar affective disorder on chromosome 21q22. (C) 2004 Lippincott Williams Wilkins.
AB - Several studies provide suggestive evidence of a susceptibility locus for bipolar disorder at chromosome 21q22-23. In an attempt to replicate these findings, we have analyzed linkage to 11 polymorphic markers from this region in 18 Bulgarian pedigrees with affective disorder. Two-point linkage analysis under assumption of homogeneity and a dominant model with reduced penetrance produced modest positive values for some of the markers tested under a 'narrow' phenotype definition, including bipolar I and II, and schizoaffective disorder. The maximum two-point score (lod = 1.76, theta = 0.00) was at marker D21S1919. Non-parametric linkage analysis under the same phenotype model, yielded positive NPLall values (P < 0.05) over the region between markers D21S211 and D21S416, with a peak at D21S1252 (NPL Zall = 2.32, P = 0.0003). The multipoint lod score (GENEHUNTER) reached a suggestive value for linkage (lod = 2.10) also at marker D21S1252. The results under a recessive model were completely negative. These data add to the evidence for the existence of a susceptibility locus for bipolar affective disorder on chromosome 21q22. (C) 2004 Lippincott Williams Wilkins.
U2 - 10.1097/01.ypg.0000128766.92096.ad
DO - 10.1097/01.ypg.0000128766.92096.ad
M3 - Article
SN - 0955-8829
VL - 14
SP - 101
EP - 106
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 2
ER -