Lifetime recreational physical activity and the risk of prostate cancer

Elizabeth Sorial, Si Si, Lin Fritschi, Ellie Darcey, Justine E. Leavy, Jennifer Girschik, Gina L. Ambrosini, Terry Boyle

Research output: Contribution to journalArticle

Abstract

Purpose: Research on the association between physical activity and the risk of prostate cancer is inconsistent. The aim of this study was to investigate whether the timing, intensity, and type of recreational physical activity influence prostate cancer risk. Methods: A population-based case–control study was conducted in Western Australia in 2001–2002. Data were collected on lifetime recreational physical activity from a self-reported questionnaire. The estimated effects of recreational physical activity on prostate cancer risk were analyzed using logistic regression, adjusting for demographic and lifestyle factors. This analysis included 569 incident cases and 443 controls. Results: There was a significant, inverse dose–response relationship between vigorous-intensity recreational physical activity between the ages 19 and 34 years and the risk of prostate cancer (p Trend = 0.013). Participants in the most active quartile of vigorous-intensity physical activity in this age period had a 33% lower risk of prostate cancer than participants in the least active quartile (Adjusted Odds Ratio = 0.67, 95% confidence interval = 0.45–1.01). Moderate-intensity recreational physical activity was not associated with the risk of prostate cancer. Recreational physical activity performed over the lifetime showed no association with prostate cancer risk. Weight training performed from early adulthood onwards showed a non-significant but consistent inverse association with prostate cancer risk. There was no strong evidence that physical activity was differentially associated with the risks of low-grade and medium-to-high grade prostate cancers. Conclusions: A high level of vigorous recreational physical activity in early adulthood may be required to reduce the risk of prostate cancer.

Original languageEnglish
Pages (from-to)617-625
Number of pages9
JournalCancer Causes and Control
Volume30
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

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Prostatic Neoplasms
Western Australia
Life Style
Logistic Models
Odds Ratio
Demography
Confidence Intervals
Weights and Measures
Research
Population

Cite this

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title = "Lifetime recreational physical activity and the risk of prostate cancer",
abstract = "Purpose: Research on the association between physical activity and the risk of prostate cancer is inconsistent. The aim of this study was to investigate whether the timing, intensity, and type of recreational physical activity influence prostate cancer risk. Methods: A population-based case–control study was conducted in Western Australia in 2001–2002. Data were collected on lifetime recreational physical activity from a self-reported questionnaire. The estimated effects of recreational physical activity on prostate cancer risk were analyzed using logistic regression, adjusting for demographic and lifestyle factors. This analysis included 569 incident cases and 443 controls. Results: There was a significant, inverse dose–response relationship between vigorous-intensity recreational physical activity between the ages 19 and 34 years and the risk of prostate cancer (p Trend = 0.013). Participants in the most active quartile of vigorous-intensity physical activity in this age period had a 33{\%} lower risk of prostate cancer than participants in the least active quartile (Adjusted Odds Ratio = 0.67, 95{\%} confidence interval = 0.45–1.01). Moderate-intensity recreational physical activity was not associated with the risk of prostate cancer. Recreational physical activity performed over the lifetime showed no association with prostate cancer risk. Weight training performed from early adulthood onwards showed a non-significant but consistent inverse association with prostate cancer risk. There was no strong evidence that physical activity was differentially associated with the risks of low-grade and medium-to-high grade prostate cancers. Conclusions: A high level of vigorous recreational physical activity in early adulthood may be required to reduce the risk of prostate cancer.",
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Lifetime recreational physical activity and the risk of prostate cancer. / Sorial, Elizabeth; Si, Si; Fritschi, Lin; Darcey, Ellie; Leavy, Justine E.; Girschik, Jennifer; Ambrosini, Gina L.; Boyle, Terry.

In: Cancer Causes and Control, Vol. 30, No. 6, 01.06.2019, p. 617-625.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lifetime recreational physical activity and the risk of prostate cancer

AU - Sorial, Elizabeth

AU - Si, Si

AU - Fritschi, Lin

AU - Darcey, Ellie

AU - Leavy, Justine E.

AU - Girschik, Jennifer

AU - Ambrosini, Gina L.

AU - Boyle, Terry

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N2 - Purpose: Research on the association between physical activity and the risk of prostate cancer is inconsistent. The aim of this study was to investigate whether the timing, intensity, and type of recreational physical activity influence prostate cancer risk. Methods: A population-based case–control study was conducted in Western Australia in 2001–2002. Data were collected on lifetime recreational physical activity from a self-reported questionnaire. The estimated effects of recreational physical activity on prostate cancer risk were analyzed using logistic regression, adjusting for demographic and lifestyle factors. This analysis included 569 incident cases and 443 controls. Results: There was a significant, inverse dose–response relationship between vigorous-intensity recreational physical activity between the ages 19 and 34 years and the risk of prostate cancer (p Trend = 0.013). Participants in the most active quartile of vigorous-intensity physical activity in this age period had a 33% lower risk of prostate cancer than participants in the least active quartile (Adjusted Odds Ratio = 0.67, 95% confidence interval = 0.45–1.01). Moderate-intensity recreational physical activity was not associated with the risk of prostate cancer. Recreational physical activity performed over the lifetime showed no association with prostate cancer risk. Weight training performed from early adulthood onwards showed a non-significant but consistent inverse association with prostate cancer risk. There was no strong evidence that physical activity was differentially associated with the risks of low-grade and medium-to-high grade prostate cancers. Conclusions: A high level of vigorous recreational physical activity in early adulthood may be required to reduce the risk of prostate cancer.

AB - Purpose: Research on the association between physical activity and the risk of prostate cancer is inconsistent. The aim of this study was to investigate whether the timing, intensity, and type of recreational physical activity influence prostate cancer risk. Methods: A population-based case–control study was conducted in Western Australia in 2001–2002. Data were collected on lifetime recreational physical activity from a self-reported questionnaire. The estimated effects of recreational physical activity on prostate cancer risk were analyzed using logistic regression, adjusting for demographic and lifestyle factors. This analysis included 569 incident cases and 443 controls. Results: There was a significant, inverse dose–response relationship between vigorous-intensity recreational physical activity between the ages 19 and 34 years and the risk of prostate cancer (p Trend = 0.013). Participants in the most active quartile of vigorous-intensity physical activity in this age period had a 33% lower risk of prostate cancer than participants in the least active quartile (Adjusted Odds Ratio = 0.67, 95% confidence interval = 0.45–1.01). Moderate-intensity recreational physical activity was not associated with the risk of prostate cancer. Recreational physical activity performed over the lifetime showed no association with prostate cancer risk. Weight training performed from early adulthood onwards showed a non-significant but consistent inverse association with prostate cancer risk. There was no strong evidence that physical activity was differentially associated with the risks of low-grade and medium-to-high grade prostate cancers. Conclusions: A high level of vigorous recreational physical activity in early adulthood may be required to reduce the risk of prostate cancer.

KW - Epidemiology

KW - Physical activity

KW - Prostate cancer

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JF - Cancer Causes & Control

SN - 0957-5243

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