Levels of advanced glycation end products in gingival crevicular fluid of chronic periodontitis patients with and without type-2 diabetes mellitus

Zohaib Akram, Fawaz Alqahtani, Mana Alqahtani, Abdulaziz A. Al-Kheraif, Fawad Javed

Research output: Contribution to journalArticlepeer-review

61 Citations (Web of Science)

Abstract

Background It is hypothesized that levels of advanced glycation end products (AGEs) are higher in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with type-2 diabetes mellitus (type-2 DM) than controls (systemically healthy individuals without CP. The aim was to assess the levels of AGEs in the GCF of CP patients with and without type-2 DM. Methods Participants were divided into three groups as follows. Group-1: Patients with type-2 DM and CP; group-2: Non-diabetic individuals with CP; group-3: Non-diabetic individuals without periodontal diseases. Demographic data were collected using a questionnaire. Full-mouth plaque-index (PI), bleeding-on-probing (BOP), probing depth (PD), clinical attachment loss (AL), and marginal-bone-loss (MBL) were assessed. Hemoglobin A1c (HbA1c) levels were recorded. The GCF was collected and levels of AGEs were assessed using standard techniques. Group comparisons were performed and P Ninety-four individuals (32, 31, and 31 individuals in groups 1, 2, and 3, respectively) were included. Mean HbA1c levels were significantly higher in group-1 than groups 2 (P

Original languageEnglish
Pages (from-to)396-402
Number of pages7
JournalJournal of Periodontology
Volume91
Issue number3
Early online date2 Sept 2019
DOIs
Publication statusPublished - Mar 2020

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