Left ventricular mass regression one year after transcatheter aortic valve implantation

Apostolos Tzikas, Marcel L. Geleijnse, Nicolas M. Van Mieghem, Carl J. Schultz, Rutger Jan Nuis, Bas M. Van Dalen, Giovanna Sarno, Ron T. Van Domburg, Patrick W. Serruys, Peter P T De Jaegere

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Abstract

Background: Left ventricular (LV) hypertrophy is associated with LV diastolic dysfunction and constitutes a risk factor for cardiac morbidity and mortality. The objective of this study was to investigate the degree of LV mass regression and the changes of LV diastolic function one year after transcatheter aortic valve implantation (TAVI). Methods Echocardiography was performed at baseline, before discharge, and at one-year follow-up in 63 consecutive patients with severe aortic stenosis who underwent TAVI with the Medtronic CoreValve System (Medtronic Inc, Minneapolis, MN). The LV mass was calculated using the Devereux formula and indexed to body surface area. Results One-year all-cause mortality was 29%. The LV mass index decreased from 126 ± 42 g/m 2 at baseline to 110 ± 30 g/m 2 at one-year follow-up (p < 0.001). Left ventricular ejection fraction and LV diastolic function did not change significantly. Mean transaortic gradient decreased from 47 ± 19 mm Hg at baseline to 9 ± 5 mm Hg at discharge and 9 ± 4 mm Hg at one year (p < 0.001), and was accompanied by significant clinical improvement. More than mild paravalvular aortic regurgitation was found in 24% and 15% of patients at discharge and one-year follow-up, respectively. Conclusions A significant regression in LV mass was found one year after TAVI. However, regression was incomplete and was not accompanied by an improvement in LV diastolic function.

Original languageEnglish
Pages (from-to)685-691
Number of pages7
JournalAnnals of Thoracic Surgery
Volume91
Issue number3
DOIs
Publication statusPublished - 1 Mar 2011
Externally publishedYes

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Tzikas, A., Geleijnse, M. L., Van Mieghem, N. M., Schultz, C. J., Nuis, R. J., Van Dalen, B. M., ... De Jaegere, P. P. T. (2011). Left ventricular mass regression one year after transcatheter aortic valve implantation. Annals of Thoracic Surgery, 91(3), 685-691. https://doi.org/10.1016/j.athoracsur.2010.09.037