Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Xiaotian Zhang, Mira Jeong, Xingfan Huang, Xue Qing Wang, Xinyu Wang, Wanding Zhou, Muhammad S. Shamim, Haley Gore, Pamela Himadewi, Yushuai Liu, Ivan D. Bochkov, Jaime Reyes, Madison Doty, Yung Hsin Huang, Haiyoung Jung, Emily Heikamp, Aviva Presser Aiden, Wei Li, Jianzhong Su, Erez Lieberman AidenMargaret A. Goodell

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Zhang et al. discovered that very large DNA methylation nadirs (grand canyons) form megabase-scale and inter-chromosomal 3D genomic interactions in primary stem and progenitor cells. H3K27me3 is strongly enriched in grand canyons and is important for organizing the grand canyon interactions associated with their stem cell state.

Original languageEnglish
Pages (from-to)506-521.e6
JournalMolecular Cell
Volume78
Issue number3
DOIs
Publication statusPublished - 7 May 2020

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