Clostridium difficile is a multi-host, anaerobic Gram-positive bacillus that evolved from one of the oldest groups of environmental bacteria. Over recent decades, C. difficile infection has risen in frequency to become a global public health threat as a cause of diarrhea mediated by large clostridial toxins (LCT) A and B. The objective of research reported in this thesis was to characterize LCT-negative, binary toxin-producing (A-B-CDT+) strains of C. difficule. These strains have been detected in patients with severe diarrhea and are highly prevalent in food animals and the environment throughout the world.
|Qualification||Doctor of Philosophy|
|Award date||28 Jan 2020|
|Publication status||Unpublished - 2020|