Laparoscopic Kidney Orthotopic Transplant: Preclinical Study in the Pig Model

B. He, G. C. Musk, L. Mou, G. L. Waneck, L. Delriviere

Research output: Contribution to journalConference article

6 Citations (Scopus)

Abstract

Background. Laparoscopic surgery has rapidly expanded in clinical practice replacing conventional open surgery over the last three decades. Laparoscopic donor nephrectomy has been favored due to its multiple benefits. The aim of this study was to explore the safety and feasibility of kidney transplantation by a laparoscopic technique in a pig model.

Materials and methods. The study was approved by the university animal ethics committee. Eight female pigs (Sus Scrofra, weighing 45-50 kg) were divided into 2 groups: group I included 4 animals that underwent laparoscopic kidney orthotopic transplantation on the left side. The right kidney was remained functional in situ. The pigs recovered and were observed for 1 week In the 4 hosts group II pigs underwent a laparoseopic kidney transplantation on the left side. With simultaneous clipping of the right ureter. After recovery, the pigs were observed for 4 weeks. A laparotomy for examination was performed prior to euthanasia.

Results. All 4 group I pigs survived for 1 week. The laparotomy showed normal graft perfusion with wall patent renal artery and vein as well as satisfactory urine output upon transection of ureter in 3 hosts. Renal artery stenosis occurred in one pig. In The Immediate kidney graft function was achieved in 3 group II pigs. The fourth died following extubation due to laryngospasm despite a functional graft. The average creatinine levels were 195.5 mu mol/L on day 3; 224.5 mu mol/L at week 1; 127 mu mol/L at week 2; 182.7 umol/L at week 3; and 154.7 umol/L at week 4.

Conclusion. Laparoscopic kidney transplantation was feasible and safe in a pig model with immediate graft function. This study will provide further evidence to support application of laparoscopic technique to human kidney transplant.
Original languageEnglish
Pages (from-to)1776-1779
Number of pages4
JournalTransplantation Proceedings
Volume45
Issue number5
DOIs
Publication statusPublished - Jun 2013
Event24th International Congress of the Transplantation Society - Berlin, Germany
Duration: 15 Jul 201219 Jul 2012

Fingerprint Dive into the research topics of 'Laparoscopic Kidney Orthotopic Transplant: Preclinical Study in the Pig Model'. Together they form a unique fingerprint.

Cite this