Lack of significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated therapy

W. Supanaranond, Y. Suputtamongkol, Timothy Davis, S. Pukrittayakamee, P. Teja-Isavadharm, H.K. Webster, N.J. White

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg)were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QT(c) interval was prolonged by a mean of 12% (SD=8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.
    Original languageEnglish
    Pages (from-to)694-696
    JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
    Volumen/a
    Issue number91
    DOIs
    Publication statusPublished - 1997

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