Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

K.A. Pettigrew; S.F. Fajutrao Valles; K. Moll; K. Northstone; S. Ring; Craig Pennell; Carol Wang; R. Leavett; M.E. Hayiou-Thomas; P.A. Thompson; N.H. Simpson; S.E. Fisher; D.F. Newbury; R. Nudel; A.P. Monaco; C. Francks; G. Baird; V. Slonims; K. Dworzynski; P.F. Bolton; E.A. Simonoff; A.E. O'Hare; J.R. Seckl; H. Cowie; A.S. Clark; J.M.M. Watson; J. Nasir; W. Cohen; A. Everitt; E.R. Hennessy; D. Shaw; P.J. Helms; Z. Simkin; G. Conti; D. Ramsden; D.V.M. Bishop; A.R. Pickles; Andrew Whitehouse; M.J. Snowling; S. Paracchini

doi:10.1111/gbb.12213

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

K.A. Pettigrew, S.F. Fajutrao Valles, K. Moll, K. Northstone, S. Ring, Craig Pennell, Carol Wang, R. Leavett, M.E. Hayiou-Thomas, P.A. Thompson, N.H. Simpson, S.E. Fisher, D.F. Newbury, R. Nudel, A.P. Monaco, C. Francks, G. Baird, V. Slonims, K. Dworzynski, P.F. BoltonE.A. Simonoff, A.E. O'Hare, J.R. Seckl, H. Cowie, A.S. Clark, J.M.M. Watson, J. Nasir, W. Cohen, A. Everitt, E.R. Hennessy, D. Shaw, P.J. Helms, Z. Simkin, G. Conti, D. Ramsden, D.V.M. Bishop, A.R. Pickles, Andrew Whitehouse, M.J. Snowling, S. Paracchini

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Abstract

© 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

Original language	English
Pages (from-to)	369-376
Journal	Genes, Brain and Behavior
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/gbb.12213
Publication status	Published - 1 Apr 2015

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Pettigrew, K. A., Fajutrao Valles, S. F., Moll, K., Northstone, K., Ring, S., Pennell, C., Wang, C., Leavett, R., Hayiou-Thomas, M. E., Thompson, P. A., Simpson, N. H., Fisher, S. E., Newbury, D. F., Nudel, R., Monaco, A. P., Francks, C., Baird, G., Slonims, V., Dworzynski, K., ... Paracchini, S. (2015). Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior, 14(4), 369-376. https://doi.org/10.1111/gbb.12213

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title = "Lack of replication for the myosin-18B association with mathematical ability in independent cohorts",

abstract = "{\textcopyright} 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.",

author = "K.A. Pettigrew and {Fajutrao Valles}, S.F. and K. Moll and K. Northstone and S. Ring and Craig Pennell and Carol Wang and R. Leavett and M.E. Hayiou-Thomas and P.A. Thompson and N.H. Simpson and S.E. Fisher and D.F. Newbury and R. Nudel and A.P. Monaco and C. Francks and G. Baird and V. Slonims and K. Dworzynski and P.F. Bolton and E.A. Simonoff and A.E. O'Hare and J.R. Seckl and H. Cowie and A.S. Clark and J.M.M. Watson and J. Nasir and W. Cohen and A. Everitt and E.R. Hennessy and D. Shaw and P.J. Helms and Z. Simkin and G. Conti and D. Ramsden and D.V.M. Bishop and A.R. Pickles and Andrew Whitehouse and M.J. Snowling and S. Paracchini",

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Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME, Thompson, PA, Simpson, NH, Fisher, SE, Newbury, DF, Nudel, R, Monaco, AP, Francks, C, Baird, G, Slonims, V, Dworzynski, K, Bolton, PF, Simonoff, EA, O'Hare, AE, Seckl, JR, Cowie, H, Clark, AS, Watson, JMM, Nasir, J, Cohen, W, Everitt, A, Hennessy, ER, Shaw, D, Helms, PJ, Simkin, Z, Conti, G, Ramsden, D, Bishop, DVM, Pickles, AR, Whitehouse, A, Snowling, MJ & Paracchini, S 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts', Genes, Brain and Behavior, vol. 14, no. 4, pp. 369-376. https://doi.org/10.1111/gbb.12213

TY - JOUR

T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

AU - Pettigrew, K.A.

AU - Fajutrao Valles, S.F.

AU - Moll, K.

AU - Northstone, K.

AU - Ring, S.

AU - Pennell, Craig

AU - Wang, Carol

AU - Leavett, R.

AU - Hayiou-Thomas, M.E.

AU - Thompson, P.A.

AU - Simpson, N.H.

AU - Fisher, S.E.

AU - Newbury, D.F.

AU - Nudel, R.

AU - Monaco, A.P.

AU - Francks, C.

AU - Baird, G.

AU - Slonims, V.

AU - Dworzynski, K.

AU - Bolton, P.F.

AU - Simonoff, E.A.

AU - O'Hare, A.E.

AU - Seckl, J.R.

AU - Cowie, H.

AU - Clark, A.S.

AU - Watson, J.M.M.

AU - Nasir, J.

AU - Cohen, W.

AU - Everitt, A.

AU - Hennessy, E.R.

AU - Shaw, D.

AU - Helms, P.J.

AU - Simkin, Z.

AU - Conti, G.

AU - Ramsden, D.

AU - Bishop, D.V.M.

AU - Pickles, A.R.

AU - Whitehouse, Andrew

AU - Snowling, M.J.

AU - Paracchini, S.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - © 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

AB - © 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

U2 - 10.1111/gbb.12213

DO - 10.1111/gbb.12213

M3 - Article

C2 - 25778778

SN - 1601-1848

VL - 14

SP - 369

EP - 376

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

IS - 4

ER -

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

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