Lack of ingrowth of retinal axons into the visually deafferented superior colliculus in young rats: a horseradish peroxidase study

S. K. Gan, A. R. Harvey

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Suction lesions of the brachium of the left superior colliculus (SC) and pretectal region were made in 6-11-day-old hooded rats. Central retinal projections were examined 15-261 days later by injecting the right eye of each rat with horseradish peroxidase. Retinal fibres were found to have regrown either within glial and connective tissue membranes which formed over the lesion cavity or across the surface of the lesion itself. The axons sometimes grew up the rostral face of the remaining SC to reach the superficial tectal layers; however, there was no significant penetration into the SC neuropil.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalNeuroscience Letters
Volume70
Issue number1
DOIs
Publication statusPublished - 25 Sep 1986
Externally publishedYes

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Superior Colliculi
Horseradish Peroxidase
Axons
Neuropil
Suction
Neuroglia
Connective Tissue
Arm
Membranes

Cite this

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T2 - a horseradish peroxidase study

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AU - Harvey, A. R.

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Y1 - 1986/9/25

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AB - Suction lesions of the brachium of the left superior colliculus (SC) and pretectal region were made in 6-11-day-old hooded rats. Central retinal projections were examined 15-261 days later by injecting the right eye of each rat with horseradish peroxidase. Retinal fibres were found to have regrown either within glial and connective tissue membranes which formed over the lesion cavity or across the surface of the lesion itself. The axons sometimes grew up the rostral face of the remaining SC to reach the superficial tectal layers; however, there was no significant penetration into the SC neuropil.

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KW - Lesion

KW - Rat

KW - Regeneration

KW - Retinal axon

KW - Superior colliculus

KW - Visual system

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