Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers

F. Grieu, S. Malaney, R. Ward, D. Joseph, Barry Iacopetta

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: The aim of this case-control study was to investigate whether the common G870A polymorphism in the Cyclin D1 gene (CCND1) is a risk factor for breast and colorectal cancers in an Australian population. Patients and Methods: A total of 339 breast and 569 colorectal cancer cases were studied, together with 327 age-matched controls. Genotyping for the G870A polymorphism in CCND1 was carried out using single strand conformation polymorphism and Pyrosequencing methods. Results: Comparison of the CCND1 G870A genotype frequencies revealed no significant associations between presence of the A allele and the risk of either breast or colorectal cancer. No associations were noted between presence of the A allele and pathological features of these tumours or patient survival. Conclusion: Although the CCND1 G870A polymorphism has been reported as a genetic risk factor for some tumour types, it does not appear to be linked to the risk of breast and colorectal cancers.
Original languageEnglish
Pages (from-to)4257-4259
JournalAnticancer research : international journal of cancer research and treatment
Volume23
Issue number5b
Publication statusPublished - 2003

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