Lab generated retina: Realizing the dream

Carla B Mellough, Joseph Collin, Evelyne Sernagor, Nicholas K Wride, David H W Steel, Majlinda Lako

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Blindness represents an increasing global problem with significant social and economic impact upon affected patients and society as a whole. In Europe, approximately one in 30 individuals experience sight loss and 75% of those are unemployed, a social burden which is very likely to increase as the population of Europe ages. Diseases affecting the retina account for approximately 26% of blindness globally and 70% of blindness in the United Kingdom. To date, there are no treatments to restore lost retinal cells and improve visual function, highlighting an urgent need for new therapeutic approaches. A pioneering breakthrough has demonstrated the ability to generate synthetic retina from pluripotent stem cells under laboratory conditions, a finding with immense relevance for basic research, in vitro disease modeling, drug discovery, and cell replacement therapies. This review summarizes the current achievements in pluripotent stem cell differentiation toward retinal cells and highlights the steps that need to be completed in order to generate human synthetic retinae with high efficiency and reproducibly from patient-specific pluripotent stem cells.

Original languageEnglish
Pages (from-to)317-332
Number of pages16
JournalVisual Neuroscience
Volume31
Issue number4-5
DOIs
Publication statusPublished - Sep 2014
Externally publishedYes

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Pluripotent Stem Cells
Blindness
Retina
Aptitude
Drug Discovery
Cell- and Tissue-Based Therapy
Cell Differentiation
Economics
Efficiency
Therapeutics
Research
Population

Cite this

Mellough, C. B., Collin, J., Sernagor, E., Wride, N. K., Steel, D. H. W., & Lako, M. (2014). Lab generated retina: Realizing the dream. Visual Neuroscience, 31(4-5), 317-332. https://doi.org/10.1017/S095252381400008X
Mellough, Carla B ; Collin, Joseph ; Sernagor, Evelyne ; Wride, Nicholas K ; Steel, David H W ; Lako, Majlinda. / Lab generated retina : Realizing the dream. In: Visual Neuroscience. 2014 ; Vol. 31, No. 4-5. pp. 317-332.
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Mellough, CB, Collin, J, Sernagor, E, Wride, NK, Steel, DHW & Lako, M 2014, 'Lab generated retina: Realizing the dream' Visual Neuroscience, vol. 31, no. 4-5, pp. 317-332. https://doi.org/10.1017/S095252381400008X

Lab generated retina : Realizing the dream. / Mellough, Carla B; Collin, Joseph; Sernagor, Evelyne; Wride, Nicholas K; Steel, David H W; Lako, Majlinda.

In: Visual Neuroscience, Vol. 31, No. 4-5, 09.2014, p. 317-332.

Research output: Contribution to journalReview article

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T1 - Lab generated retina

T2 - Realizing the dream

AU - Mellough, Carla B

AU - Collin, Joseph

AU - Sernagor, Evelyne

AU - Wride, Nicholas K

AU - Steel, David H W

AU - Lako, Majlinda

PY - 2014/9

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AB - Blindness represents an increasing global problem with significant social and economic impact upon affected patients and society as a whole. In Europe, approximately one in 30 individuals experience sight loss and 75% of those are unemployed, a social burden which is very likely to increase as the population of Europe ages. Diseases affecting the retina account for approximately 26% of blindness globally and 70% of blindness in the United Kingdom. To date, there are no treatments to restore lost retinal cells and improve visual function, highlighting an urgent need for new therapeutic approaches. A pioneering breakthrough has demonstrated the ability to generate synthetic retina from pluripotent stem cells under laboratory conditions, a finding with immense relevance for basic research, in vitro disease modeling, drug discovery, and cell replacement therapies. This review summarizes the current achievements in pluripotent stem cell differentiation toward retinal cells and highlights the steps that need to be completed in order to generate human synthetic retinae with high efficiency and reproducibly from patient-specific pluripotent stem cells.

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KW - Blindness

KW - Cell Differentiation

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KW - Neurons

KW - Pluripotent Stem Cells

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KW - Review

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Mellough CB, Collin J, Sernagor E, Wride NK, Steel DHW, Lako M. Lab generated retina: Realizing the dream. Visual Neuroscience. 2014 Sep;31(4-5):317-332. https://doi.org/10.1017/S095252381400008X