Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers

J.W. Cox; Susan Berners-Price; M.S. Davies; Y. Qu; N. Farrell

doi:10.1021/ja0012772

Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers

J.W. Cox, Susan Berners-Price, M.S. Davies, Y. Qu, N. Farrell

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Original language	English
Pages (from-to)	1316-1326
Journal	Journal American Chemical Society
Volume	123
DOIs	https://doi.org/10.1021/ja0012772
Publication status	Published - 2001

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10.1021/ja0012772

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Cox, J. W., Berners-Price, S., Davies, M. S., Qu, Y., & Farrell, N. (2001). Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers. Journal American Chemical Society, 123, 1316-1326. https://doi.org/10.1021/ja0012772

Cox, J.W. ; Berners-Price, Susan ; Davies, M.S. et al. / Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers. In: Journal American Chemical Society. 2001 ; Vol. 123. pp. 1316-1326.

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title = "Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers",

author = "J.W. Cox and Susan Berners-Price and M.S. Davies and Y. Qu and N. Farrell",

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Cox, JW, Berners-Price, S, Davies, MS, Qu, Y & Farrell, N 2001, 'Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers', Journal American Chemical Society, vol. 123, pp. 1316-1326. https://doi.org/10.1021/ja0012772

Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers. / Cox, J.W.; Berners-Price, Susan; Davies, M.S. et al.

In: Journal American Chemical Society, Vol. 123, 2001, p. 1316-1326.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers

AU - Cox, J.W.

AU - Berners-Price, Susan

AU - Davies, M.S.

AU - Qu, Y.

AU - Farrell, N.

PY - 2001

Y1 - 2001

U2 - 10.1021/ja0012772

DO - 10.1021/ja0012772

M3 - Article

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JO - Journal of the Amercian Chemical Society

JF - Journal of the Amercian Chemical Society

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Cox JW, Berners-Price S, Davies MS, Qu Y, Farrell N. Kinetic Analysis of the Stepwise Formation of a Long-Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers. Journal American Chemical Society. 2001;123:1316-1326. https://doi.org/10.1021/ja0012772