Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

Santana A.L. Thomas, Jacqueline L. Von Salm, Shane Clark, Steve Ferlita, Prasanth Nemani, Ala Azhari, Christopher A. Rice, Nerida G. Wilson, Dennis E. Kyle, Bill J. Baker

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3 Citations (Scopus)

Abstract

During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalJournal of Natural Products
Volume81
Issue number1
DOIs
Publication statusPublished - 26 Jan 2018

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    Thomas, S. A. L., Von Salm, J. L., Clark, S., Ferlita, S., Nemani, P., Azhari, A., Rice, C. A., Wilson, N. G., Kyle, D. E., & Baker, B. J. (2018). Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima. Journal of Natural Products, 81(1), 117-123. https://doi.org/10.1021/acs.jnatprod.7b00732