TY - JOUR
T1 - Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
AU - Thomas, Santana A.L.
AU - Von Salm, Jacqueline L.
AU - Clark, Shane
AU - Ferlita, Steve
AU - Nemani, Prasanth
AU - Azhari, Ala
AU - Rice, Christopher A.
AU - Wilson, Nerida G.
AU - Kyle, Dennis E.
AU - Baker, Bill J.
PY - 2018/1/26
Y1 - 2018/1/26
N2 - During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.
AB - During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.
UR - http://www.scopus.com/inward/record.url?scp=85041241292&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00732
DO - 10.1021/acs.jnatprod.7b00732
M3 - Article
C2 - 29260557
AN - SCOPUS:85041241292
SN - 0163-3864
VL - 81
SP - 117
EP - 123
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 1
ER -